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Synthesis and Applications of Cell Compatible Peptide Assemblies.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis and Applications of Cell Compatible Peptide Assemblies./
Author:	Yang, Dongsik.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	179 p.
Notes:	Source: Dissertations Abstracts International, Volume: 83-04, Section: B.
Contained By:	Dissertations Abstracts International83-04B.
Subject:	Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28547012
ISBN:	9798460409860

Synthesis and Applications of Cell Compatible Peptide Assemblies.
Yang, Dongsik.

Synthesis and Applications of Cell Compatible Peptide Assemblies. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 179 p.

Source: Dissertations Abstracts International, Volume: 83-04, Section: B.

Thesis (Ph.D.)--Brandeis University, 2021.

This item must not be sold to any third party vendors.

In the field of peptide assemblies, there have been a lot of attempts to form and explore the various assemblies, composed of not only natural peptides but also peptide derivatives. While the earlier efforts focused on the morphologies of the assemblies; recently, the attentions to the novel functions derived from the assemblies and the processes of assembling has increased significantly, which leads to the exploration of new applications. For my thesis work, I designed and synthesized small molecules that formed supramolecular assemblies. There are five chapters in the dissertation. Chapter 1 gives a comprehensive review on supramolecular peptide assemblies of peptides or peptide derivatives, which have emerged as one of most active research areas in supramolecular chemistry and soft matter. Chapter 2 describes a supramolecular approach for controlling cellular processes and provides insights for mimicking chaperones and controlling protein−protein interactions. Chapter 3 demonstrates a new type of tryptophan-rich short peptides, which act as hydrogelators, form supramolecular assemblies via enzymatic dephosphorylation, and exhibit cell compatibility. Chapter 4 reports that the use of an enzymatic reaction to cleave the branch off branched peptides for inducing the morphological transition of the assemblies of the peptides. Chapter 5 focuses on conclusive summary on supramolecular peptide assemblies and their applications as well as their future outlooks.

ISBN: 9798460409860Subjects--Topical Terms:

518028
Biochemistry.
Subjects--Index Terms:

Assemblies

Synthesis and Applications of Cell Compatible Peptide Assemblies.
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245 1 0 $a Synthesis and Applications of Cell Compatible Peptide Assemblies.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 179 p.
500 $a Source: Dissertations Abstracts International, Volume: 83-04, Section: B.
500 $a Advisor: Xu, Bing.
502 $a Thesis (Ph.D.)--Brandeis University, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a In the field of peptide assemblies, there have been a lot of attempts to form and explore the various assemblies, composed of not only natural peptides but also peptide derivatives. While the earlier efforts focused on the morphologies of the assemblies; recently, the attentions to the novel functions derived from the assemblies and the processes of assembling has increased significantly, which leads to the exploration of new applications. For my thesis work, I designed and synthesized small molecules that formed supramolecular assemblies. There are five chapters in the dissertation. Chapter 1 gives a comprehensive review on supramolecular peptide assemblies of peptides or peptide derivatives, which have emerged as one of most active research areas in supramolecular chemistry and soft matter. Chapter 2 describes a supramolecular approach for controlling cellular processes and provides insights for mimicking chaperones and controlling protein−protein interactions. Chapter 3 demonstrates a new type of tryptophan-rich short peptides, which act as hydrogelators, form supramolecular assemblies via enzymatic dephosphorylation, and exhibit cell compatibility. Chapter 4 reports that the use of an enzymatic reaction to cleave the branch off branched peptides for inducing the morphological transition of the assemblies of the peptides. Chapter 5 focuses on conclusive summary on supramolecular peptide assemblies and their applications as well as their future outlooks.
590 $a School code: 0021.
650 4 $a Biochemistry. $3 518028
650 4 $a Cellular biology. $3 3172791
650 4 $a Biomedical engineering. $3 535387
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Molecular biology. $3 517296
653 $a Assemblies
653 $a Cell compatibility
653 $a Peptide
653 $a Protein
690 $a 0487
690 $a 0379
690 $a 0541
690 $a 0307
690 $a 0572
710 2 $a Brandeis University. $b Chemistry. $3 1669782
773 0 $t Dissertations Abstracts International $g 83-04B.
790 $a 0021
791 $a Ph.D.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28547012