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Clinical Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implant Disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Clinical Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implant Disease./
Author:	Garcia, Marcos.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	84 p.
Notes:	Source: Masters Abstracts International, Volume: 83-02.
Contained By:	Masters Abstracts International83-02.
Subject:	Dentistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28644277
ISBN:	9798522945121

Clinical Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implant Disease.
Garcia, Marcos.

Clinical Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implant Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 84 p.

Source: Masters Abstracts International, Volume: 83-02.

Thesis (M.Sc.D.)--The University of Texas School of Dentistry at Houston, 2021.

This item must not be sold to any third party vendors.

Background: Laser antimicrobial photodynamic therapy has been advocated as an adjunct to traditional mechanical debridement of implants suffering from peri-implant inflammation. This study aims to compare clinical outcomes specifically changes in bleeding on probing (BOP) and pocket depth (PD) after mechanical debridement of implant surfaces at sites exhibiting plaque induced inflammation with or without adjunctive laser antimicrobial photodynamic therapy (aPDT).Methods: This a randomized double blinded clinical control study designed to assess improved clinical outcomes with the use of aPDT as an adjunct to mechanical debridement in the treatment of peri-implant diseases. Thirty-four (34) patients were recruited. Clinical measurements including bleeding on probing (BOP), pocket depth (PD), and plaque were measured at baseline, 6 weeks, and 12 weeks after therapy. The 2017 Periodontology World Workshop classification was used to diagnose implants as peri-implant mucositis or peri-implantitis. Only diseased implants were included and only one implant per patient was studied. Our hypothesis is that implant sites diagnosed with either peri-implant mucositis or peri-implantitis treated with mechanical debridement and adjunctive aPDT will have greater reduction in BOP and PD than those sites treated with mechanical debridement alone.Results: For the peri-implantitis group there was no statistically significant difference in clinical parameters between test and control groups (P ≤ 0.05) between time points. For the peri-implant mucositis group, there was no statistically significant difference in clinical parameters between test and control groups (p ≤ 0.05) between time points. Correlation noted between an increasing plaque count and increased BOP (p = 0.0022), PD mean (p = 0.0184), and deepest PD (p = 0.05). In the peri-implantitis group, generalized linear mixed model statistical analysis showed that comparing between baseline and 6 weeks and 12-week time points, there was an overall statistically significant reduction in BOP (p < 0.02), PD mean (p < 0.0005), and deepest PD (p < 0.007). For the peri-implant mucositis group, analysis showed that comparing between baseline and 6 weeks and 12-week time points, there was an overall statistically significant reduction in BOP (p < 0.001), PD mean (p < 0.0005), deepest PD (p < 0.007), and plaque count (p < 0.014).Conclusion: Non-surgical treatment of both peri-implant mucositis and peri-implantitis is effective in decreasing peri-implant inflammation and improving clinical parameters of BOP, PD, and plaque. There was no statistically significant difference in clinical outcomes between those implants treated with adjunctive aPDT and those treated without adjunctive aPDT.

ISBN: 9798522945121Subjects--Topical Terms:

828971
Dentistry.
Subjects--Index Terms:

Implant

Clinical Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implant Disease.
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245 1 0 $a Clinical Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implant Disease.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 84 p.
500 $a Source: Masters Abstracts International, Volume: 83-02.
500 $a Advisor: Eswaran, Sridhar.
502 $a Thesis (M.Sc.D.)--The University of Texas School of Dentistry at Houston, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Background: Laser antimicrobial photodynamic therapy has been advocated as an adjunct to traditional mechanical debridement of implants suffering from peri-implant inflammation. This study aims to compare clinical outcomes specifically changes in bleeding on probing (BOP) and pocket depth (PD) after mechanical debridement of implant surfaces at sites exhibiting plaque induced inflammation with or without adjunctive laser antimicrobial photodynamic therapy (aPDT).Methods: This a randomized double blinded clinical control study designed to assess improved clinical outcomes with the use of aPDT as an adjunct to mechanical debridement in the treatment of peri-implant diseases. Thirty-four (34) patients were recruited. Clinical measurements including bleeding on probing (BOP), pocket depth (PD), and plaque were measured at baseline, 6 weeks, and 12 weeks after therapy. The 2017 Periodontology World Workshop classification was used to diagnose implants as peri-implant mucositis or peri-implantitis. Only diseased implants were included and only one implant per patient was studied. Our hypothesis is that implant sites diagnosed with either peri-implant mucositis or peri-implantitis treated with mechanical debridement and adjunctive aPDT will have greater reduction in BOP and PD than those sites treated with mechanical debridement alone.Results: For the peri-implantitis group there was no statistically significant difference in clinical parameters between test and control groups (P ≤ 0.05) between time points. For the peri-implant mucositis group, there was no statistically significant difference in clinical parameters between test and control groups (p ≤ 0.05) between time points. Correlation noted between an increasing plaque count and increased BOP (p = 0.0022), PD mean (p = 0.0184), and deepest PD (p = 0.05). In the peri-implantitis group, generalized linear mixed model statistical analysis showed that comparing between baseline and 6 weeks and 12-week time points, there was an overall statistically significant reduction in BOP (p < 0.02), PD mean (p < 0.0005), and deepest PD (p < 0.007). For the peri-implant mucositis group, analysis showed that comparing between baseline and 6 weeks and 12-week time points, there was an overall statistically significant reduction in BOP (p < 0.001), PD mean (p < 0.0005), deepest PD (p < 0.007), and plaque count (p < 0.014).Conclusion: Non-surgical treatment of both peri-implant mucositis and peri-implantitis is effective in decreasing peri-implant inflammation and improving clinical parameters of BOP, PD, and plaque. There was no statistically significant difference in clinical outcomes between those implants treated with adjunctive aPDT and those treated without adjunctive aPDT.
590 $a School code: 1707.
650 4 $a Dentistry. $3 828971
650 4 $a Therapy. $3 3343697
650 4 $a Health care management. $3 2122906
650 4 $a Pathogens. $3 3540520
650 4 $a Acids. $3 922327
650 4 $a Transplants & implants. $3 3562683
650 4 $a Semiconductors. $3 516162
650 4 $a Biofilms. $3 660574
650 4 $a Cytokines. $3 687114
650 4 $a Bacteria. $3 550366
650 4 $a Biological products. $3 656054
650 4 $a Aluminum. $3 735071
650 4 $a Surgical outcomes. $3 3562650
650 4 $a Energy. $3 876794
650 4 $a Teeth. $3 1640005
650 4 $a Radiation. $3 673904
650 4 $a Clinical outcomes. $3 3682127
650 4 $a Patients. $3 1961957
650 4 $a Hemoglobin. $3 1012003
650 4 $a Antibiotics. $3 670318
650 4 $a Carbon dioxide. $3 587886
650 4 $a Clinical trials. $3 724498
650 4 $a Antimicrobial agents. $3 3556833
650 4 $a Photodynamic therapy. $3 3685023
650 4 $a Systematic review. $3 3680549
650 4 $a Atoms & subatomic particles. $3 3560412
653 $a Implant
653 $a Laser
653 $a Inflammation
653 $a Mucositis
653 $a Peri-implantitis
690 $a 0567
690 $a 0212
690 $a 0769
690 $a 0791
710 2 $a The University of Texas School of Dentistry at Houston. $b Periodontics. $3 3685022
773 0 $t Masters Abstracts International $g 83-02.
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791 $a M.Sc.D.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28644277