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Discovery of small-molecule modulato...

Byun, Wan Gi.

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Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19

Record Type:	Electronic resources : Monograph/item
Title/Author:	Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19/ by Wan Gi Byun.
Author:	Byun, Wan Gi.
Published:	Singapore :Springer Nature Singapore : : 2023.,
Description:	xxxii, 128 p. :ill., digital ;24 cm.
Notes:	"Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"
[NT 15003449]:	1. Introduction -- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28-Let-7 Interaction -- 3. Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay -- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2 -- Appendix.
Contained By:	Springer Nature eBook
Subject:	RNA-protein interactions. -
Online resource:	https://doi.org/10.1007/978-981-19-7814-2
ISBN:	9789811978142

Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19
Byun, Wan Gi.

Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19[electronic resource] /by Wan Gi Byun. - Singapore :Springer Nature Singapore :2023. - xxxii, 128 p. :ill., digital ;24 cm. - Springer theses,2190-5061. - Springer theses..

"Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"

1. Introduction -- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28-Let-7 Interaction -- 3. Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay -- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2 -- Appendix.

This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19. Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.

ISBN: 9789811978142

Standard No.: 10.1007/978-981-19-7814-2doiSubjects--Topical Terms:

569547
RNA-protein interactions.

LC Class. No.: QP623.8.P75 / B98 2023

Dewey Class. No.: 572.633

Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19
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505 0 $a 1. Introduction -- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28-Let-7 Interaction -- 3. Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay -- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2 -- Appendix.
520 $a This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19. Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.
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