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Sequence-specific DNA binders for th...

Hidaka, Takuya.

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Sequence-specific DNA binders for the therapy of mitochondrial diseases

Record Type:	Electronic resources : Monograph/item
Title/Author:	Sequence-specific DNA binders for the therapy of mitochondrial diseases/ by Takuya Hidaka.
Author:	Hidaka, Takuya.
Published:	Singapore :Springer Singapore : : 2022.,
Description:	xiii, 94 p. :ill., digital ;24 cm.
[NT 15003449]:	General Introduction -- Creation of Synthetic Ligand for Mitochondrial DNA sequence Recognition and Promoter-Specific Transcription Suppression -- Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation Reagent -- Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of the Tri-arginine Vector.
Contained By:	Springer Nature eBook
Subject:	Mitochondrial pathology - Genetic aspects. -
Online resource:	https://doi.org/10.1007/978-981-16-8436-4
ISBN:	9789811684364

Sequence-specific DNA binders for the therapy of mitochondrial diseases
Hidaka, Takuya.

Sequence-specific DNA binders for the therapy of mitochondrial diseases[electronic resource] /by Takuya Hidaka. - Singapore :Springer Singapore :2022. - xiii, 94 p. :ill., digital ;24 cm. - Springer theses,2190-5061. - Springer theses..

General Introduction -- Creation of Synthetic Ligand for Mitochondrial DNA sequence Recognition and Promoter-Specific Transcription Suppression -- Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation Reagent -- Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of the Tri-arginine Vector.

This book describes the author's work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole-imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells. This work will attract readers' interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the author's studies and to perform similar and extended studies themselves.

ISBN: 9789811684364

Standard No.: 10.1007/978-981-16-8436-4doiSubjects--Topical Terms:

841796
Mitochondrial pathology
--Genetic aspects.

LC Class. No.: RB147.5 / .H53 2022

Dewey Class. No.: 616.042

Sequence-specific DNA binders for the therapy of mitochondrial diseases
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100 1 $a Hidaka, Takuya. $3 3591847
245 1 0 $a Sequence-specific DNA binders for the therapy of mitochondrial diseases $h [electronic resource] / $c by Takuya Hidaka.
260 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2022.
300 $a xiii, 94 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5061
505 0 $a General Introduction -- Creation of Synthetic Ligand for Mitochondrial DNA sequence Recognition and Promoter-Specific Transcription Suppression -- Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation Reagent -- Enhanced Nuclear Accumulation of Pyrrole-Imidazole Polyamides by Incorporation of the Tri-arginine Vector.
520 $a This book describes the author's work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole-imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells. This work will attract readers' interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the author's studies and to perform similar and extended studies themselves.
650 0 $a Mitochondrial pathology $x Genetic aspects. $3 841796
650 0 $a Mitochondrial DNA $x Abnormalities. $3 841795
650 0 $a Polyamides. $3 750338
650 0 $a Gene therapy. $3 600619
650 1 4 $a Chemistry/Food Science, general. $3 894122
650 2 4 $a Biomaterials. $3 898413
650 2 4 $a Genetics and Genomics. $3 3385208
650 2 4 $a Cell Biology. $3 892383
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a Springer theses. $3 1314442
856 4 0 $u https://doi.org/10.1007/978-981-16-8436-4
950 $a Chemistry and Materials Science (SpringerNature-11644)