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The Analysis of Post-Translational M...

Collop, Paul.

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The Analysis of Post-Translational Modifications in Protein Biotherapeutics Using Hilic-Ms.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Analysis of Post-Translational Modifications in Protein Biotherapeutics Using Hilic-Ms./
Author:	Collop, Paul.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	98 p.
Notes:	Source: Masters Abstracts International, Volume: 82-08.
Contained By:	Masters Abstracts International82-08.
Subject:	Analytical chemistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28025744
ISBN:	9798569915217

The Analysis of Post-Translational Modifications in Protein Biotherapeutics Using Hilic-Ms.
Collop, Paul.

The Analysis of Post-Translational Modifications in Protein Biotherapeutics Using Hilic-Ms. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 98 p.

Source: Masters Abstracts International, Volume: 82-08.

Thesis (M.S.)--University of Georgia, 2020.

This item must not be sold to any third party vendors.

The maintenance of higher order structure (HOS) in proteins is vital to performance,activity, and function in biological systems. Monoclonal antibodies (mAbs) are biotherapeuticmonoclonal antibodies that are used to fight diseases such as cancer and rheumatoid arthritis.mAbs comprise a large piece of the pharmaceutical drug market, with projected sales expected toreach $130-220 billion USD by the year 2022. Deleterious modifications that occur on theprimary level of these protein substrates alter their tertiary and quaternary structure influencingactivity. The development of laboratory methods for the quantitation of post-translationalmodifications are essential to the monitoring and quantitation of post-translational modificationsin pharmaceutical products. HPLC-MS has proven effective in the rapid analysis of proteins andtheir modifications. The measurable difference in mass along with physical separation of thesesubstrates with Liquid Chromatography (LC) allows mass spectrometry-based analysis methodsto be used.

ISBN: 9798569915217Subjects--Topical Terms:

3168300
Analytical chemistry.
Subjects--Index Terms:

Deamidation

The Analysis of Post-Translational Modifications in Protein Biotherapeutics Using Hilic-Ms.
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100 1 $a Collop, Paul. $3 3562745
245 1 4 $a The Analysis of Post-Translational Modifications in Protein Biotherapeutics Using Hilic-Ms.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 98 p.
500 $a Source: Masters Abstracts International, Volume: 82-08.
500 $a Advisor: Orlando, Ron.
502 $a Thesis (M.S.)--University of Georgia, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a The maintenance of higher order structure (HOS) in proteins is vital to performance,activity, and function in biological systems. Monoclonal antibodies (mAbs) are biotherapeuticmonoclonal antibodies that are used to fight diseases such as cancer and rheumatoid arthritis.mAbs comprise a large piece of the pharmaceutical drug market, with projected sales expected toreach $130-220 billion USD by the year 2022. Deleterious modifications that occur on theprimary level of these protein substrates alter their tertiary and quaternary structure influencingactivity. The development of laboratory methods for the quantitation of post-translationalmodifications are essential to the monitoring and quantitation of post-translational modificationsin pharmaceutical products. HPLC-MS has proven effective in the rapid analysis of proteins andtheir modifications. The measurable difference in mass along with physical separation of thesesubstrates with Liquid Chromatography (LC) allows mass spectrometry-based analysis methodsto be used.
590 $a School code: 0077.
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Biochemistry. $3 518028
653 $a Deamidation
653 $a Liquid chromatography
653 $a Mass spectrometry
653 $a Monoclonal antibodies
653 $a Proteomics
653 $a Post-translational modifications
690 $a 0486
690 $a 0487
710 2 $a University of Georgia. $b Chemistry - MS. $3 3562746
773 0 $t Masters Abstracts International $g 82-08.
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791 $a M.S.
792 $a 2020
793 $a English
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