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Whole-Genome Sequencing Approach to ...

Gene, Mathew.

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Whole-Genome Sequencing Approach to Characterize the Population Structure of Bacillus cereus at a Human Milk Bank.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Whole-Genome Sequencing Approach to Characterize the Population Structure of Bacillus cereus at a Human Milk Bank./
Author:	Gene, Mathew.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	137 p.
Notes:	Source: Masters Abstracts International, Volume: 83-01.
Contained By:	Masters Abstracts International83-01.
Subject:	Biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28418559
ISBN:	9798522945619

Whole-Genome Sequencing Approach to Characterize the Population Structure of Bacillus cereus at a Human Milk Bank.
Gene, Mathew.

Whole-Genome Sequencing Approach to Characterize the Population Structure of Bacillus cereus at a Human Milk Bank. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 137 p.

Source: Masters Abstracts International, Volume: 83-01.

Thesis (M.Sc.)--University of Toronto (Canada), 2021.

This item must not be sold to any third party vendors.

Stringent milk handling protocols including pasteurization are used at human milk banks serving critically-ill, preterm neonates. However, up to 30% of donated human milk is lost to contamination with the potentially neonatal pathogen Bacillus cereus, whose spores can resist pasteurization. Here, we used genomics to evaluate the population structure of a collection of B. cereus organisms recovered from pre- and post-pasteurized human milk donated to a human milk bank, from patients seeking care at that facility and from the hospital environment. Pangenome analysis revealed an unexpectedly high level of genetic diversity within the milk bank/hospital strain population. Phylogenetic analyses using core-genome polymorphisms did not permit identification of sources of human milk contamination by B. cereus. Genome-wide association studies revealed that variants of genes involved in sporulation are overrepresented among organisms recovered from post-pasteurized milk. The results may be used to improve milk banking protocols and research around the world.

ISBN: 9798522945619Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Bacillus cereus

Whole-Genome Sequencing Approach to Characterize the Population Structure of Bacillus cereus at a Human Milk Bank.
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300 $a 137 p.
500 $a Source: Masters Abstracts International, Volume: 83-01.
500 $a Advisor: Fittipaldi, Nahuel V.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Stringent milk handling protocols including pasteurization are used at human milk banks serving critically-ill, preterm neonates. However, up to 30% of donated human milk is lost to contamination with the potentially neonatal pathogen Bacillus cereus, whose spores can resist pasteurization. Here, we used genomics to evaluate the population structure of a collection of B. cereus organisms recovered from pre- and post-pasteurized human milk donated to a human milk bank, from patients seeking care at that facility and from the hospital environment. Pangenome analysis revealed an unexpectedly high level of genetic diversity within the milk bank/hospital strain population. Phylogenetic analyses using core-genome polymorphisms did not permit identification of sources of human milk contamination by B. cereus. Genome-wide association studies revealed that variants of genes involved in sporulation are overrepresented among organisms recovered from post-pasteurized milk. The results may be used to improve milk banking protocols and research around the world.
590 $a School code: 0779.
650 4 $a Biology. $3 522710
650 4 $a Bioinformatics. $3 553671
650 4 $a Genetics. $3 530508
650 4 $a Infections. $3 1621997
650 4 $a Pathogens. $3 3540520
650 4 $a Metadata. $3 590006
650 4 $a Food products. $3 3562092
650 4 $a Food contamination & poisoning. $3 3562624
650 4 $a Sepsis. $3 3560733
650 4 $a Bacteria. $3 550366
650 4 $a Nutrition. $3 517777
650 4 $a Hospitals. $3 616081
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650 4 $a Mothers. $3 598165
650 4 $a Plasmids. $3 3319070
650 4 $a Pneumonia. $3 871060
650 4 $a Baby foods. $3 1046917
650 4 $a Decades. $3 3562625
650 4 $a Classification. $3 595585
650 4 $a Taxonomy. $3 3556303
650 4 $a Anthrax. $3 3562626
650 4 $a Biotechnology. $3 571461
650 4 $a Polymorphism. $3 3560380
650 4 $a Babies. $3 3556699
653 $a Bacillus cereus
653 $a Milk banking
653 $a Pangenome
653 $a Phylogenetics
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710 2 $a University of Toronto (Canada). $b Cell and Systems Biology. $3 3283151
773 0 $t Masters Abstracts International $g 83-01.
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