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Generating a Mouse Model of Symptoma...

Collier, Crystal Marie Destiny.

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Generating a Mouse Model of Symptomatic and Asymptomatic Intracerebral Hemorrhage by Applying High-Pressure Focused Ultrasound.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Generating a Mouse Model of Symptomatic and Asymptomatic Intracerebral Hemorrhage by Applying High-Pressure Focused Ultrasound./
Author:	Collier, Crystal Marie Destiny.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	101 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
Contained By:	Dissertations Abstracts International82-12B.
Subject:	Neurosciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28495225
ISBN:	9798505537855

Generating a Mouse Model of Symptomatic and Asymptomatic Intracerebral Hemorrhage by Applying High-Pressure Focused Ultrasound.
Collier, Crystal Marie Destiny.

Generating a Mouse Model of Symptomatic and Asymptomatic Intracerebral Hemorrhage by Applying High-Pressure Focused Ultrasound. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 101 p.

Source: Dissertations Abstracts International, Volume: 82-12, Section: B.

Thesis (Ph.D.)--Columbia University, 2021.

This item must not be sold to any third party vendors.

Intracerebral hemorrhage defines a category of neurological disease that spans the full range of possible clinical outcomes. At one end of the spectrum is hemorrhagic stroke, an often debilitating neurologic condition with substantial morbidity and mortality while cerebral microhemorrhage at the other end of the spectrum can go completely unnoticed as they are often asymptomatic. Despite the distinct clinical outcomes both conditions share a common risk factor, uncontrolled hypertension. Here we set out to generate a novel mouse model of intracerebral hemorrhage with pressure as the mode of hemorrhage induction. To conduct our studies, we utilize high pressure focused ultrasound in combination with injected microbubbles to cause hemorrhage. We applied this technique at two different pressures resulting in striatal hemorrhage induction with distinct phenotypic outcomes. Following induction at the higher-pressure, mice show evidence of lateral motor deficit and other signs of impairment. Mice with hemorrhage induced at the lower pressure show no behavioral signs of neurological deficit. We employ immunofluorescence and western blotting to understand the cellular responses to intracerebral hemorrhage in these mice. We find evidence of inflammation and cell death following high-pressure induction of intracerebral hemorrhage. Lower pressure induction of intracerebral hemorrhage lacks signs of cell death but shows apparent inflammation. We have created a novel pressure-dependent mouse model of symptomatic and asymptomatic intracerebral hemorrhage by applying high intensity focused ultrasound in combination with circulating microbubbles.

ISBN: 9798505537855Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Focused ultrasound

Generating a Mouse Model of Symptomatic and Asymptomatic Intracerebral Hemorrhage by Applying High-Pressure Focused Ultrasound.
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245 1 0 $a Generating a Mouse Model of Symptomatic and Asymptomatic Intracerebral Hemorrhage by Applying High-Pressure Focused Ultrasound.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 101 p.
500 $a Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
500 $a Advisor: Troy, Carol.
502 $a Thesis (Ph.D.)--Columbia University, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Intracerebral hemorrhage defines a category of neurological disease that spans the full range of possible clinical outcomes. At one end of the spectrum is hemorrhagic stroke, an often debilitating neurologic condition with substantial morbidity and mortality while cerebral microhemorrhage at the other end of the spectrum can go completely unnoticed as they are often asymptomatic. Despite the distinct clinical outcomes both conditions share a common risk factor, uncontrolled hypertension. Here we set out to generate a novel mouse model of intracerebral hemorrhage with pressure as the mode of hemorrhage induction. To conduct our studies, we utilize high pressure focused ultrasound in combination with injected microbubbles to cause hemorrhage. We applied this technique at two different pressures resulting in striatal hemorrhage induction with distinct phenotypic outcomes. Following induction at the higher-pressure, mice show evidence of lateral motor deficit and other signs of impairment. Mice with hemorrhage induced at the lower pressure show no behavioral signs of neurological deficit. We employ immunofluorescence and western blotting to understand the cellular responses to intracerebral hemorrhage in these mice. We find evidence of inflammation and cell death following high-pressure induction of intracerebral hemorrhage. Lower pressure induction of intracerebral hemorrhage lacks signs of cell death but shows apparent inflammation. We have created a novel pressure-dependent mouse model of symptomatic and asymptomatic intracerebral hemorrhage by applying high intensity focused ultrasound in combination with circulating microbubbles.
590 $a School code: 0054.
650 4 $a Neurosciences. $3 588700
650 4 $a Pathology. $3 643180
650 4 $a Biomedical engineering. $3 535387
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653 $a Microbleed
653 $a Model
653 $a Mouse
653 $a Stroke
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