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Impact of Genetic Variation in the E...

Mansouri, Esmaeil.

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Impact of Genetic Variation in the Endocannabinoid- Degrading Enzyme FAAH on Dopamine D2/3 Receptor Status: Neuroimaging Studies in Human and Mice with Implications for Addictions.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Impact of Genetic Variation in the Endocannabinoid- Degrading Enzyme FAAH on Dopamine D2/3 Receptor Status: Neuroimaging Studies in Human and Mice with Implications for Addictions./
Author:	Mansouri, Esmaeil.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	125 p.
Notes:	Source: Masters Abstracts International, Volume: 82-06.
Contained By:	Masters Abstracts International82-06.
Subject:	Nanoscience. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28031309
ISBN:	9798698546818

Impact of Genetic Variation in the Endocannabinoid- Degrading Enzyme FAAH on Dopamine D2/3 Receptor Status: Neuroimaging Studies in Human and Mice with Implications for Addictions.
Mansouri, Esmaeil.

Impact of Genetic Variation in the Endocannabinoid- Degrading Enzyme FAAH on Dopamine D2/3 Receptor Status: Neuroimaging Studies in Human and Mice with Implications for Addictions. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 125 p.

Source: Masters Abstracts International, Volume: 82-06.

Thesis (M.Sc.)--University of Toronto (Canada), 2020.

This item must not be sold to any third party vendors.

BACKGROUND: The endocannabinoid and dopaminergic systems have independently been implicated in addiction. We investigated a potential interaction between a genetically inherited variation in fatty acid amide hydrolase (FAAH C385A), the enzyme which metabolizes the endocannabinoid anandamide, and dopamine receptor status in brain.METHODS: Brain binding of the dopamine D3-preferring probe [C-11]-(+)-PHNO was measured with positron emission tomography (PET) in 79 healthy participants genotyped for the FAAH C385A polymorphism. Autoradiography with [H-3]-(+)-PHNO and in situ hybridization with a D3-specific S-35 riboprobe were carried out in a FAAH knock-in mouse model replicating the FAAH C385A polymorphism.RESULTS: Humans and knock-in mice with the C385A variant showed reduced FAAH activity demonstrated higher dopamine D3 receptors.CONCLUSIONS: Results may provide a mechanistic link between dopamine and endocannabinoid systems and explain greater risk for addiction with lower FAAH (C385A variant).

ISBN: 9798698546818Subjects--Topical Terms:

587832
Nanoscience.
Subjects--Index Terms:

Endocannabinoid systems

Impact of Genetic Variation in the Endocannabinoid- Degrading Enzyme FAAH on Dopamine D2/3 Receptor Status: Neuroimaging Studies in Human and Mice with Implications for Addictions.
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506 $a This item must not be sold to any third party vendors.
520 $a BACKGROUND: The endocannabinoid and dopaminergic systems have independently been implicated in addiction. We investigated a potential interaction between a genetically inherited variation in fatty acid amide hydrolase (FAAH C385A), the enzyme which metabolizes the endocannabinoid anandamide, and dopamine receptor status in brain.METHODS: Brain binding of the dopamine D3-preferring probe [C-11]-(+)-PHNO was measured with positron emission tomography (PET) in 79 healthy participants genotyped for the FAAH C385A polymorphism. Autoradiography with [H-3]-(+)-PHNO and in situ hybridization with a D3-specific S-35 riboprobe were carried out in a FAAH knock-in mouse model replicating the FAAH C385A polymorphism.RESULTS: Humans and knock-in mice with the C385A variant showed reduced FAAH activity demonstrated higher dopamine D3 receptors.CONCLUSIONS: Results may provide a mechanistic link between dopamine and endocannabinoid systems and explain greater risk for addiction with lower FAAH (C385A variant).
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