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Lidocaine Mucoadhesive Film Fabricat...

Alyahya, Mohammed .

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Lidocaine Mucoadhesive Film Fabrication Using Fused Deposition Modeling 3d Printing.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Lidocaine Mucoadhesive Film Fabrication Using Fused Deposition Modeling 3d Printing./
Author:	Alyahya, Mohammed .
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	50 p.
Notes:	Source: Masters Abstracts International, Volume: 82-04.
Contained By:	Masters Abstracts International82-04.
Subject:	Pharmaceutical sciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27836813
ISBN:	9798672182834

Lidocaine Mucoadhesive Film Fabrication Using Fused Deposition Modeling 3d Printing.
Alyahya, Mohammed .

Lidocaine Mucoadhesive Film Fabrication Using Fused Deposition Modeling 3d Printing. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 50 p.

Source: Masters Abstracts International, Volume: 82-04.

Thesis (M.S.)--The University of Mississippi, 2020.

This item must not be sold to any third party vendors.

Hot-melt extrusion and 3D printing are among the recent means of processing techniques adopted in the pharmaceutical industry. These technologies are used as a method of preparing solid dispersions develop complex shapes that are difficult to be obtained using other means of production. In the current research work, many formulations loaded with lidocaine HCl were prepared and extruded using 11mm twin-screw extruder. The extrudate filaments were then fed into a fused deposition modelling (FDM) printer to fabricate mucoadhesive films meant to buccal applications to manage local pain within the oral cavity that requires the intervention with local anesthetics. The printed films drug content was determined using HPLC, films drug content was within the acceptable limits. Furthermore, the drug release was assessed using an in-house method. All test formulations revealed an excellent release profile of the lidocaine HCl, reaching more than 90% within 5-15 min. The films adhesion and mechanical properties were tested using texture analyzer. The results indicated that the films possess an adequate mechanical property to satisfy its intended use. In conclusion, this research work demonstrates that coupling hot-melting extruder to a fused deposition modelling printing is feasible to produce lidocaine-loaded buccal mucoadhesive films intended for local application in the oral cavity.

ISBN: 9798672182834Subjects--Topical Terms:

3173021
Pharmaceutical sciences.
Subjects--Index Terms:

3D printing

Lidocaine Mucoadhesive Film Fabrication Using Fused Deposition Modeling 3d Printing.
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300 $a 50 p.
500 $a Source: Masters Abstracts International, Volume: 82-04.
500 $a Advisor: Repka, Michael;Ashour, Eman.
502 $a Thesis (M.S.)--The University of Mississippi, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Hot-melt extrusion and 3D printing are among the recent means of processing techniques adopted in the pharmaceutical industry. These technologies are used as a method of preparing solid dispersions develop complex shapes that are difficult to be obtained using other means of production. In the current research work, many formulations loaded with lidocaine HCl were prepared and extruded using 11mm twin-screw extruder. The extrudate filaments were then fed into a fused deposition modelling (FDM) printer to fabricate mucoadhesive films meant to buccal applications to manage local pain within the oral cavity that requires the intervention with local anesthetics. The printed films drug content was determined using HPLC, films drug content was within the acceptable limits. Furthermore, the drug release was assessed using an in-house method. All test formulations revealed an excellent release profile of the lidocaine HCl, reaching more than 90% within 5-15 min. The films adhesion and mechanical properties were tested using texture analyzer. The results indicated that the films possess an adequate mechanical property to satisfy its intended use. In conclusion, this research work demonstrates that coupling hot-melting extruder to a fused deposition modelling printing is feasible to produce lidocaine-loaded buccal mucoadhesive films intended for local application in the oral cavity.
590 $a School code: 0131.
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Computer science. $3 523869
653 $a 3D printing
653 $a Buccal delivery
653 $a Buccal film
653 $a FDM
653 $a Hot-melt extrusion
653 $a Mucoadhesive
690 $a 0572
690 $a 0984
710 2 $a The University of Mississippi. $b Pharmaceutical Science. $3 3557997
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