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How Sweet It Is: The Role of Taste P...

May, Christina E.

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How Sweet It Is: The Role of Taste Perception in Diet-Induced Obesity.

Record Type:	Electronic resources : Monograph/item
Title/Author:	How Sweet It Is: The Role of Taste Perception in Diet-Induced Obesity./
Author:	May, Christina E.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	214 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-07, Section: B.
Contained By:	Dissertations Abstracts International82-07B.
Subject:	Public health. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28240214
ISBN:	9798684625350

How Sweet It Is: The Role of Taste Perception in Diet-Induced Obesity.
May, Christina E.

How Sweet It Is: The Role of Taste Perception in Diet-Induced Obesity. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 214 p.

Source: Dissertations Abstracts International, Volume: 82-07, Section: B.

Thesis (Ph.D.)--University of Michigan, 2020.

This item must not be sold to any third party vendors.

Our ability to taste sugar evolved to tell us that certain foods are good to eat because they provide us with energy. However, in the modern food environment of ubiquitous "added sugars", this good taste can be hijacked in ways that cause overeating. This dissertation details the discovery of a means by which dietary sugar causes overeating in the fruit fly Drosophila melanogaster, via impairment of peripheral sweet taste sensitivity through increased intracellular glucose metabolic signaling by a conserved protein modifier. This in turn affects central value/motivational processing of the sweet sensation to alter feeding. We also present a new fly feeding assay, the optoFLIC, that is optimized for the monitoring and the closed-loop, optogenetic manipulation of long-term, steady-state feeding behaviors. Together, these findings depict a theory overeating that links excess dietary sugar with peripheral sensation and central reward, and they guide future research into the etiology and treatment of diet-induced obesity.

ISBN: 9798684625350Subjects--Topical Terms:

534748
Public health.
Subjects--Index Terms:

Sugar

How Sweet It Is: The Role of Taste Perception in Diet-Induced Obesity.
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245 1 0 $a How Sweet It Is: The Role of Taste Perception in Diet-Induced Obesity.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 214 p.
500 $a Source: Dissertations Abstracts International, Volume: 82-07, Section: B.
500 $a Advisor: Dus, Monica.
502 $a Thesis (Ph.D.)--University of Michigan, 2020.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Our ability to taste sugar evolved to tell us that certain foods are good to eat because they provide us with energy. However, in the modern food environment of ubiquitous "added sugars", this good taste can be hijacked in ways that cause overeating. This dissertation details the discovery of a means by which dietary sugar causes overeating in the fruit fly Drosophila melanogaster, via impairment of peripheral sweet taste sensitivity through increased intracellular glucose metabolic signaling by a conserved protein modifier. This in turn affects central value/motivational processing of the sweet sensation to alter feeding. We also present a new fly feeding assay, the optoFLIC, that is optimized for the monitoring and the closed-loop, optogenetic manipulation of long-term, steady-state feeding behaviors. Together, these findings depict a theory overeating that links excess dietary sugar with peripheral sensation and central reward, and they guide future research into the etiology and treatment of diet-induced obesity.
590 $a School code: 0127.
650 4 $a Public health. $3 534748
650 4 $a Neurosciences. $3 588700
650 4 $a Epidemiology. $3 568544
650 4 $a Behavioral sciences. $3 529833
650 4 $a Nutrition. $3 517777
653 $a Sugar
653 $a Diet
653 $a Drosophila melanogaster
653 $a Glucose metabolism
653 $a Energy from food
653 $a Sweet taste sensitivity
653 $a Intracellular glucose
653 $a Obesity
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710 2 $a University of Michigan. $b Neuroscience. $3 3347026
773 0 $t Dissertations Abstracts International $g 82-07B.
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791 $a Ph.D.
792 $a 2020
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