東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Antioxidant-Loaded Nanoparticles for...

Liao, Rick.

Linked to FindBook

Google Book

Amazon

博客來

Antioxidant-Loaded Nanoparticles for the Treatment of Excitotoxicity in Neurological Disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Antioxidant-Loaded Nanoparticles for the Treatment of Excitotoxicity in Neurological Disease./
Author:	Liao, Rick.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	130 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-04, Section: B.
Contained By:	Dissertations Abstracts International82-04B.
Subject:	Chemical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28001866
ISBN:	9798684649363

Antioxidant-Loaded Nanoparticles for the Treatment of Excitotoxicity in Neurological Disease.
Liao, Rick.

Antioxidant-Loaded Nanoparticles for the Treatment of Excitotoxicity in Neurological Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 130 p.

Source: Dissertations Abstracts International, Volume: 82-04, Section: B.

Thesis (Ph.D.)--University of Washington, 2020.

This item must not be sold to any third party vendors.

In the United States alone, neurological diseases affect tens of millions of people, costing $800 billion annually. In acute neurological injury, a process known as excitotoxicity manifests from energy failure or direct trauma, causing overexcitation of neurons that leads to neuronal toxicity. Following neuronal death, toxic metabolites and cellular debris accumulate in the brain, perpetuating excitotoxicity to neighboring neurons. Despite the heavy social and economic toll and extensive research into neurotherapeutic development, there are currently no approved therapeutics for targeting excitotoxicity after acute neurological injury. The difficulty in clinical translation is largely attributed to several barriers intrinsic to the brain, including traversing the blood-brain barrier (BBB) and diffusion through the brain parenchyma. Therefore, in addition to understanding the biological complexity of the brain, developing effective therapeutics is a drug delivery problem.To expedite the pre-clinical research process, we have developed a tailorable organotypic whole hemisphere (OWH) brain slice model, capable of mimicking in vivo processes including excitotoxity and neuroinflammation. Using OWH models, we can systematically study disease processes and screen therapeutics in a high-throughput fashion, bypassing delivery obstacles. To improve therapeutic enzyme delivery, we have developed brain-penetrating antioxidant enzyme-loaded polymeric nanoparticles that inhibit enzymatic degradation. Furthermore, via nanoparticle screening on the OWH model, we have elucidated the toxicity of a common polymeric nanoparticle formulation involving poly(ethylene glycol) (PEG) and sonication, and developed alternative biocompatible nanoparticle formulations. Finally, the OWH model has enabled detailed observation of disease-dependent nanoparticle-microglia interactions that can better inform drug delivery strategies. Throughout these studies, we have implemented a transdisciplinary approach that emphasizes thorough understanding of the neurobiology of disease and leverages chemical engineering fundamentals, to ultimately advance neurotherapeutic development.

ISBN: 9798684649363Subjects--Topical Terms:

560457
Chemical engineering.
Subjects--Index Terms:

Drug delivery

Antioxidant-Loaded Nanoparticles for the Treatment of Excitotoxicity in Neurological Disease.
LDR:03382nmm a2200385 4500 001 2278379
005 20210628075012.5
008 220723s2020 ||||||||||||||||| ||eng d
020 $a 9798684649363
035 $a (MiAaPQ)AAI28001866
035 $a AAI28001866
040 $a MiAaPQ $c MiAaPQ
100 1 $a Liao, Rick. $3 3556756
245 1 0 $a Antioxidant-Loaded Nanoparticles for the Treatment of Excitotoxicity in Neurological Disease.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 130 p.
500 $a Source: Dissertations Abstracts International, Volume: 82-04, Section: B.
500 $a Advisor: Nance, Elizabeth.
502 $a Thesis (Ph.D.)--University of Washington, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a In the United States alone, neurological diseases affect tens of millions of people, costing $800 billion annually. In acute neurological injury, a process known as excitotoxicity manifests from energy failure or direct trauma, causing overexcitation of neurons that leads to neuronal toxicity. Following neuronal death, toxic metabolites and cellular debris accumulate in the brain, perpetuating excitotoxicity to neighboring neurons. Despite the heavy social and economic toll and extensive research into neurotherapeutic development, there are currently no approved therapeutics for targeting excitotoxicity after acute neurological injury. The difficulty in clinical translation is largely attributed to several barriers intrinsic to the brain, including traversing the blood-brain barrier (BBB) and diffusion through the brain parenchyma. Therefore, in addition to understanding the biological complexity of the brain, developing effective therapeutics is a drug delivery problem.To expedite the pre-clinical research process, we have developed a tailorable organotypic whole hemisphere (OWH) brain slice model, capable of mimicking in vivo processes including excitotoxity and neuroinflammation. Using OWH models, we can systematically study disease processes and screen therapeutics in a high-throughput fashion, bypassing delivery obstacles. To improve therapeutic enzyme delivery, we have developed brain-penetrating antioxidant enzyme-loaded polymeric nanoparticles that inhibit enzymatic degradation. Furthermore, via nanoparticle screening on the OWH model, we have elucidated the toxicity of a common polymeric nanoparticle formulation involving poly(ethylene glycol) (PEG) and sonication, and developed alternative biocompatible nanoparticle formulations. Finally, the OWH model has enabled detailed observation of disease-dependent nanoparticle-microglia interactions that can better inform drug delivery strategies. Throughout these studies, we have implemented a transdisciplinary approach that emphasizes thorough understanding of the neurobiology of disease and leverages chemical engineering fundamentals, to ultimately advance neurotherapeutic development.
590 $a School code: 0250.
650 4 $a Chemical engineering. $3 560457
650 4 $a Neurosciences. $3 588700
650 4 $a Nanotechnology. $3 526235
650 4 $a Nanoparticles. $3 605747
653 $a Drug delivery
653 $a Enzymes
653 $a Excitotoxicity
653 $a Nanoparticles
653 $a Neuroinflammation
653 $a Neurological disease
690 $a 0542
690 $a 0317
690 $a 0652
710 2 $a University of Washington. $b Chemical Engineering. $3 3178392
773 0 $t Dissertations Abstracts International $g 82-04B.
790 $a 0250
791 $a Ph.D.
792 $a 2020
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28001866