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Exploring the Immunosuppressive Prop...

Nichols, James Matthew.

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Exploring the Immunosuppressive Properties of Various Agents in the Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Exploring the Immunosuppressive Properties of Various Agents in the Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis./
Author:	Nichols, James Matthew.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	144 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
Contained By:	Dissertations Abstracts International81-11B.
Subject:	Immunology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27835389
ISBN:	9798643195979

Exploring the Immunosuppressive Properties of Various Agents in the Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis.
Nichols, James Matthew.

Exploring the Immunosuppressive Properties of Various Agents in the Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 144 p.

Source: Dissertations Abstracts International, Volume: 81-11, Section: B.

Thesis (Ph.D.)--Mississippi State University, 2020.

This item must not be sold to any third party vendors.

One of the major focuses for our lab involves examining the immunosuppressive properties of various agents and receptors in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). This dissertation encompasses an investigation of cannabidiol in the EAE model, the endocannabinoid CB1 receptor in the EAE model, staphylococcal superantigens (SAgs) as immunosuppressive agents, and various aspects of the EAE model. The first chapter covers the existing literature pertinent to these studies, the second and third chapters cover the material, methods, and results from the studies, and the fourth chapter is a discussion of how those results fit into the existing body of literature. A fifth chapter has also been included which covers two additional studies designed to develop alternative EAE models for our lab; however, both studies turned out differently than expected. One of the most interesting developments from this final chapter was the discovery of an age dependent difference in the memory T cell response of older mice, which allows for more robust disease to be induced when cells from 6 month old mice are used in the passive EAE (P-EAE) model as opposed to mice 10 weeks of age.

ISBN: 9798643195979Subjects--Topical Terms:

611031
Immunology.
Subjects--Index Terms:

Cannabinoids

Exploring the Immunosuppressive Properties of Various Agents in the Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis.
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500 $a Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
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