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Discovery and Design of Multifunctio...

Lee, Ernest.

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Discovery and Design of Multifunctional Membrane-Active and Immunomodulatory Peptides and Proteins.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Discovery and Design of Multifunctional Membrane-Active and Immunomodulatory Peptides and Proteins./
Author:	Lee, Ernest.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	262 p.
Notes:	Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
Contained By:	Dissertations Abstracts International79-11B.
Subject:	Bioengineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10785702
ISBN:	9780355846232

Discovery and Design of Multifunctional Membrane-Active and Immunomodulatory Peptides and Proteins.
Lee, Ernest.

Discovery and Design of Multifunctional Membrane-Active and Immunomodulatory Peptides and Proteins. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 262 p.

Source: Dissertations Abstracts International, Volume: 79-11, Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2018.

This item is not available from ProQuest Dissertations & Theses.

The human innate immune system consists of several components, which include antimicrobial peptides, pattern-recognition receptors, cytokines, and immune cells. In this dissertation, we explore unifying themes underlying the antimicrobial, membrane remodeling, and immunomodulatory behaviors of antimicrobial peptides and related molecules, and their interactions with microbial and mammalian cells. We utilize machine learning on antimicrobial peptides to examine the physicochemical parameters characteristic of membrane curvature generation, and develop a search tool to discover hidden antimicrobial and membrane-remodeling activity in new and existing taxonomies of multifunctional peptides and proteins, including mitochondrial fission proteins, histones, and neuropeptides. Using structural characterization and calibrating immune cell stimulation experiments, we outline molecular rules for antimicrobial peptide-mediated immunomodulation via ligand clustering of nucleic acids. Antimicrobial peptides condense naked DNA, nucleosomal DNA, and dsRNA into nanocrystalline immunocomplexes, which drastically amplify inflammation via multivalent binding to Toll-like receptors in immune cells. This work has broad implications for the deterministic control of inflammation in the contexts of infection, chronic inflammation, and autoimmune disease.

ISBN: 9780355846232Subjects--Topical Terms:

657580
Bioengineering.
Subjects--Index Terms:

Antimicrobial peptides

Discovery and Design of Multifunctional Membrane-Active and Immunomodulatory Peptides and Proteins.
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245 1 0 $a Discovery and Design of Multifunctional Membrane-Active and Immunomodulatory Peptides and Proteins.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 262 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Wong, Gerard C.L.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2018.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a The human innate immune system consists of several components, which include antimicrobial peptides, pattern-recognition receptors, cytokines, and immune cells. In this dissertation, we explore unifying themes underlying the antimicrobial, membrane remodeling, and immunomodulatory behaviors of antimicrobial peptides and related molecules, and their interactions with microbial and mammalian cells. We utilize machine learning on antimicrobial peptides to examine the physicochemical parameters characteristic of membrane curvature generation, and develop a search tool to discover hidden antimicrobial and membrane-remodeling activity in new and existing taxonomies of multifunctional peptides and proteins, including mitochondrial fission proteins, histones, and neuropeptides. Using structural characterization and calibrating immune cell stimulation experiments, we outline molecular rules for antimicrobial peptide-mediated immunomodulation via ligand clustering of nucleic acids. Antimicrobial peptides condense naked DNA, nucleosomal DNA, and dsRNA into nanocrystalline immunocomplexes, which drastically amplify inflammation via multivalent binding to Toll-like receptors in immune cells. This work has broad implications for the deterministic control of inflammation in the contexts of infection, chronic inflammation, and autoimmune disease.
590 $a School code: 0031.
650 4 $a Bioengineering. $3 657580
650 4 $a Biophysics. $3 518360
650 4 $a Immunology. $3 611031
653 $a Antimicrobial peptides
653 $a Autoimmune diseases
653 $a Innate immunity
653 $a Machine learning
653 $a Multifunctional proteins
653 $a Toll-like receptors
690 $a 0202
690 $a 0786
690 $a 0982
710 2 $a University of California, Los Angeles. $b Bioengineering. $3 3180839
773 0 $t Dissertations Abstracts International $g 79-11B.
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791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10785702