東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Potential molecular mechanisms under...

Hamilton, Andrew William.

FindBook

Google Book

Amazon

博客來

Potential molecular mechanisms underlying environmental disruption of the stress response endocrine system in wild flatfish of Southern California's urban ocean.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Potential molecular mechanisms underlying environmental disruption of the stress response endocrine system in wild flatfish of Southern California's urban ocean./
作者:	Hamilton, Andrew William.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2008,
面頁冊數:	65 p.
附註:	Source: Masters Abstracts International, Volume: 70-07.
Contained By:	Masters Abstracts International70-07.
標題:	Molecular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1459079
ISBN:	9780549822967

Potential molecular mechanisms underlying environmental disruption of the stress response endocrine system in wild flatfish of Southern California's urban ocean.
Hamilton, Andrew William.

Potential molecular mechanisms underlying environmental disruption of the stress response endocrine system in wild flatfish of Southern California's urban ocean. - Ann Arbor : ProQuest Dissertations & Theses, 2008 - 65 p.

Source: Masters Abstracts International, Volume: 70-07.

Thesis (M.S.)--California State University, Long Beach, 2008.

This item must not be sold to any third party vendors.

Impairment of endocrine responses to stress in southern California marine fish has been linked to anthropogenic disturbances, such as exposure to environments impacted by wastewater treatment plants (WWTPs). In order to study the possible molecular mechanisms underlying this endocrine disruption, three key steroidogenic enzyme cDNAs involved in cortisol synthesis (StAR, P45011p, and 11j3-HSD-2) were cloned from interrenal tissue (contains cortisol steroidogenic cells) of English sole (Parophyrus vetulus) and hornyhead turbot (Pleuronichthys verticalis) and real-time quantitative PCR (qPCR) assays were developed. In English sole sampled from a WWTP outfall site, impaired cortisol responses were associated with significantly altered interrenal expression of all 3 genes, indicative of impaired steroidogenic capacity. In hornyhead turbot, highly reduced interrenal StAR mRNA expression relative to that in English sole was associated with severely diminished cortisol responses at all study sites. These studies point to potential molecular targets of endocrine-disrupting compounds present in southern California's marine environment.

ISBN: 9780549822967Subjects--Topical Terms:

517296
Molecular biology.

Potential molecular mechanisms underlying environmental disruption of the stress response endocrine system in wild flatfish of Southern California's urban ocean.
LDR:02343nmm a2200337 4500 001 2270836
005 20201007134024.5
008 220629s2008 ||||||||||||||||| ||eng d
020 $a 9780549822967
035 $a (MiAaPQ)AAI1459079
035 $a AAI1459079
040 $a MiAaPQ $c MiAaPQ
100 1 $a Hamilton, Andrew William. $3 3548211
245 1 0 $a Potential molecular mechanisms underlying environmental disruption of the stress response endocrine system in wild flatfish of Southern California's urban ocean.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2008
300 $a 65 p.
500 $a Source: Masters Abstracts International, Volume: 70-07.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Kelley, Kevin.
502 $a Thesis (M.S.)--California State University, Long Beach, 2008.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Impairment of endocrine responses to stress in southern California marine fish has been linked to anthropogenic disturbances, such as exposure to environments impacted by wastewater treatment plants (WWTPs). In order to study the possible molecular mechanisms underlying this endocrine disruption, three key steroidogenic enzyme cDNAs involved in cortisol synthesis (StAR, P45011p, and 11j3-HSD-2) were cloned from interrenal tissue (contains cortisol steroidogenic cells) of English sole (Parophyrus vetulus) and hornyhead turbot (Pleuronichthys verticalis) and real-time quantitative PCR (qPCR) assays were developed. In English sole sampled from a WWTP outfall site, impaired cortisol responses were associated with significantly altered interrenal expression of all 3 genes, indicative of impaired steroidogenic capacity. In hornyhead turbot, highly reduced interrenal StAR mRNA expression relative to that in English sole was associated with severely diminished cortisol responses at all study sites. These studies point to potential molecular targets of endocrine-disrupting compounds present in southern California's marine environment.
590 $a School code: 6080.
650 4 $a Molecular biology. $3 517296
650 4 $a Environmental science. $3 677245
650 4 $a Aquatic sciences. $3 3174300
690 $a 0307
690 $a 0768
690 $a 0792
710 2 $a California State University, Long Beach. $3 1017843
773 0 $t Masters Abstracts International $g 70-07.
790 $a 6080
791 $a M.S.
792 $a 2008
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1459079