東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Brain, Behavioral, and Affective Cor...

Thompson, Benjamin L.

FindBook

Google Book

Amazon

博客來

Brain, Behavioral, and Affective Correlates of Recovery from Alcohol Use Disorders.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Brain, Behavioral, and Affective Correlates of Recovery from Alcohol Use Disorders./
作者:	Thompson, Benjamin L.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	184 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-12, Section: B.
Contained By:	Dissertations Abstracts International81-12B.
標題:	Behavioral sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27833246
ISBN:	9798645480493

Brain, Behavioral, and Affective Correlates of Recovery from Alcohol Use Disorders.
Thompson, Benjamin L.

Brain, Behavioral, and Affective Correlates of Recovery from Alcohol Use Disorders. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 184 p.

Source: Dissertations Abstracts International, Volume: 81-12, Section: B.

Thesis (Ph.D.)--Boston University, 2020.

This item must not be sold to any third party vendors.

Alcohol Use Disorders (AUDs) generally are understood as disordered behaviors, and recovery from AUDs frequently is regarded in terms of positive and constructive changes in those behaviors. However, a large proportion of recovering individuals describe the experience of recovery from AUDs as consisting of both behavioral and affective changes. The affective changes that characterize recovery have been referred to as constituting "emotional sobriety", which can be understood as a type of dynamic equilibrium with respect to the variability of the valence and intensity of affective experiences. Here, we describe neuroanatomical and behavioral correlates of emotional sobriety, as well as sex differences, through three independent but complimentary studies. In Study 1, we examined the association between the duration of abstinence (DOA) from alcohol and volumetric measures of the Brain Reward System (BRS) and its subregions, among groups of normal control (NC; n = 60) and AUD participants (n = 60). We found volumetric differences of BRS regions known to be involved in affective processing in association with different DOA. For example, long-term abstainers (greater than five years) exhibited less volume in the cingulate cortex, relative to NCs, and AUD women exhibited higher insular volume than AUD men in association with abstinence. In Study 2, we examined the association between abstinence and differences in affective states. Short-/mid-term abstainers (less than five years) exhibited affective dysregulation, relative to NCs, whereas long-term abstainers exhibited relatively normal affective states. AUD women exhibited higher positive affect than AUD men in association with abstinence. In Study 3, we examined the independent influence of mutual-help organization (MHO) activity upon affective states, over and above the effect observed in association with abstinence. Greater degrees of MHO activity were observed to be associated with increases in measures of positive affect, and sex differences also were detected in this association, with AUD women exhibiting higher positive affect than AUD men. Altogether, the findings of this dissertation indicate that the behavioral and affective changes that characterize recovery from AUDs emerge together in a dynamic, recursive interrelationship that is mediated through discrete corresponding neuroadaptations at the level of the BRS.

ISBN: 9798645480493Subjects--Topical Terms:

529833
Behavioral sciences.
Subjects--Index Terms:

Addiction

Brain, Behavioral, and Affective Correlates of Recovery from Alcohol Use Disorders.
LDR:03562nmm a2200361 4500 001 2270119
005 20200921070629.5
008 220629s2020 ||||||||||||||||| ||eng d
020 $a 9798645480493
035 $a (MiAaPQ)AAI27833246
035 $a AAI27833246
040 $a MiAaPQ $c MiAaPQ
100 1 $a Thompson, Benjamin L. $3 3547491
245 1 0 $a Brain, Behavioral, and Affective Correlates of Recovery from Alcohol Use Disorders.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 184 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-12, Section: B.
500 $a Advisor: Oscar-Berman, Marlene.
502 $a Thesis (Ph.D.)--Boston University, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Alcohol Use Disorders (AUDs) generally are understood as disordered behaviors, and recovery from AUDs frequently is regarded in terms of positive and constructive changes in those behaviors. However, a large proportion of recovering individuals describe the experience of recovery from AUDs as consisting of both behavioral and affective changes. The affective changes that characterize recovery have been referred to as constituting "emotional sobriety", which can be understood as a type of dynamic equilibrium with respect to the variability of the valence and intensity of affective experiences. Here, we describe neuroanatomical and behavioral correlates of emotional sobriety, as well as sex differences, through three independent but complimentary studies. In Study 1, we examined the association between the duration of abstinence (DOA) from alcohol and volumetric measures of the Brain Reward System (BRS) and its subregions, among groups of normal control (NC; n = 60) and AUD participants (n = 60). We found volumetric differences of BRS regions known to be involved in affective processing in association with different DOA. For example, long-term abstainers (greater than five years) exhibited less volume in the cingulate cortex, relative to NCs, and AUD women exhibited higher insular volume than AUD men in association with abstinence. In Study 2, we examined the association between abstinence and differences in affective states. Short-/mid-term abstainers (less than five years) exhibited affective dysregulation, relative to NCs, whereas long-term abstainers exhibited relatively normal affective states. AUD women exhibited higher positive affect than AUD men in association with abstinence. In Study 3, we examined the independent influence of mutual-help organization (MHO) activity upon affective states, over and above the effect observed in association with abstinence. Greater degrees of MHO activity were observed to be associated with increases in measures of positive affect, and sex differences also were detected in this association, with AUD women exhibiting higher positive affect than AUD men. Altogether, the findings of this dissertation indicate that the behavioral and affective changes that characterize recovery from AUDs emerge together in a dynamic, recursive interrelationship that is mediated through discrete corresponding neuroadaptations at the level of the BRS.
590 $a School code: 0017.
650 4 $a Behavioral sciences. $3 529833
653 $a Addiction
653 $a Alcohol
653 $a Brain reward system
653 $a Emotional sobriety
653 $a Mutual-help organizations
653 $a Recovery
690 $a 0602
710 2 $a Boston University. $b Behavioral Neurosciences GMS. $3 3547492
773 0 $t Dissertations Abstracts International $g 81-12B.
790 $a 0017
791 $a Ph.D.
792 $a 2020
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27833246