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Ultrasound-mediated Microbubble Drug...

Mintsopoulos, Victoria.

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Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome./
作者:	Mintsopoulos, Victoria.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	156 p.
附註:	Source: Masters Abstracts International, Volume: 81-06.
Contained By:	Masters Abstracts International81-06.
標題:	Medicine. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13902741
ISBN:	9781392575369

Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome.
Mintsopoulos, Victoria.

Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 156 p.

Source: Masters Abstracts International, Volume: 81-06.

Thesis (M.Sc.)--University of Toronto (Canada), 2019.

This item must not be sold to any third party vendors.

Acute respiratory distress syndrome (ARDS) is a common diagnosis in ICUs and has a mortality rate approaching 40%. This disease is characterized by a build-up of fluid in the alveolar sacs. Most patients exhibit heterogeneous injury, with relatively normal-appearing areas abutting densely consolidated regions. This heterogeneity makes treatment difficult. Ultrasound-destruction of microbubbles (USMB) has been demonstrated to increase drug uptake by tissues but has never been attempted in the lung. We hypothesized that USMB would only increase drug uptake in edematous lung regions, since air scatters ultrasound waves. USMB increased the deposition and efficacy of low dose gentamicin in the lungs of an E. coli-induced ARDS mouse model. Further, we validated the use of USMB drug delivery to the injured lung in a porcine pneumonia model, suggesting feasibility in humans. USMB may therefore allow for targeted delivery of therapies - antibiotics, antivirals, genes - to the injured lung in ARDS.

ISBN: 9781392575369Subjects--Topical Terms:

641104
Medicine.
Subjects--Index Terms:

Aminoglycoside

Ultrasound-mediated Microbubble Drug Delivery to the Injured Lung in Acute Respiratory Distress Syndrome.
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