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Neurophysiology of Face Processing i...

Khuvis, Simon.

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Neurophysiology of Face Processing in Humans.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Neurophysiology of Face Processing in Humans./
作者:	Khuvis, Simon.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	226 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-10, Section: B.
Contained By:	Dissertations Abstracts International81-10B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27829806
ISBN:	9781658491464

Neurophysiology of Face Processing in Humans.
Khuvis, Simon.

Neurophysiology of Face Processing in Humans. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 226 p.

Source: Dissertations Abstracts International, Volume: 81-10, Section: B.

Thesis (Ph.D.)--Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 2020.

This item must not be sold to any third party vendors.

Brain visual areas including the fusiform face area (FFA) in humans and its monkey homolog contain neurons that respond almost exclusively to faces. Non-human primate studies have revealed that the neurons of the middle face patch code for different face identities, while human fMRI and intracranial EEG studies have demonstrated that ventral temporal cortex (VTC) face-selective regions reactivate when subjects visualize and freely recall images of faces. However, no single unit studies of the human VTC have been described in the literature, and as a consequence, the specificity of this response at the single-unit level in humans has never been characterized. We performed single-unit recordings in the fusiform gyri of eight subjects undergoing intracranial monitoring for epilepsy, while they performed a 1-back viewing task using faces and other non-face stimuli. Most (26) of the 33 category-selective units that we recorded were selective for face stimuli. A wide diversity of face-selective responses were observed, including units that are suppressed to faces, units that continue firing after face offset and units that respond specifically to face image offset. A classifier trained on face responses of all visually-responsive units correctly identified specific held-out face identities (exemplars) at high accuracy based on the responses of the neural ensemble, showing that different exemplars have different representations in the VTC. Four subjects performed a free recall/visual imagery task in which they were presented images of famous faces and places, and, later, prompted to recall and visualize them. Face-selective units from the presentation phase of the task reactivated 2 s before the onset of face recall utterances. A classifier trained on responses to faces from the presentation phase of the task correctly predicted the identities of upcoming faces when tested on neural activity from the 2 s before a face recall utterance in two subjects. This shows that the neural code for individual faces is reactivated during recall. In a test of holistic processing of faces, our subjects performed a 1-back task using upright and inverted objects. Confirming studies in non-human primates, face-selective units showed a lower firing rate to inverted faces. Overall, our findings show that face-selective regions of the VTC are the substrate for face representations in the brain and can be recruited by sensory and top-down processes as needed.

ISBN: 9781658491464Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Epilepsy

Neurophysiology of Face Processing in Humans.
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