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Behavioral and Socio-Ecological Determinants of Depression at Different Stages of the Life Course.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Behavioral and Socio-Ecological Determinants of Depression at Different Stages of the Life Course./
作者:	Cong, Xiao.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	183 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-08, Section: B.
Contained By:	Dissertations Abstracts International80-08B.
標題:	Health sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13426677
ISBN:	9780438817241

Behavioral and Socio-Ecological Determinants of Depression at Different Stages of the Life Course.
Cong, Xiao.

Behavioral and Socio-Ecological Determinants of Depression at Different Stages of the Life Course. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 183 p.

Source: Dissertations Abstracts International, Volume: 80-08, Section: B.

Thesis (Ph.D.)--State University of New York at Albany, 2019.

This item must not be sold to any third party vendors.

Background: Depression is a critical public health concern. However, epidemiologic research has only recently begun to investigate the etiology of depression within a life course framework. In addition, although many studies have inspected the behavioral and social origins of depression, questions remain about the effects of certain factors, such as parental care, dietary intake, and neighborhood conditions, on depression. Objectives: The three projects in this dissertation aim to investigate the relationship between behavioral and socio-ecological determinants of depression at different stages of the life course from distinct perspectives. Project 1 and Project 2 aim to investigate the long-term effects of parental involvement and inflammatory diet in childhood respectively on depression in early adulthood. Project 3 aims to investigate the cross-sectional relationship between neighborhood walking environment and elevated depressive symptoms among adult residents and to inspect whether diabetes mediates or modifies this relationship. Methods: In projects 1, we utilized data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Children born in the early 1990s in Avon County, England, were enrolled. Parental involvement was assessed based on data (e.g. frequencies mother and father sing/draw/play with the child) collected across seven times from children's birth to age 7 years. Depression was measured via the ICD-10 diagnosis and the computerized version of the clinical interview schedule-revised (CIS-R) in early adulthood (age 18 years). Multiple imputations (MIs) were used to restrict bias due to loss-to-follow-up. Logistic regression models were used to prospectively investigate the relationship between level of parental involvement and risk of depression with potential confounders adjusted. In project 2, we also utilized the ALSPAC data. An inflammatory dietary pattern (IDP) was empirically derived via reduced rank regression (RRR) from dietary intake measured at age 8.5 years and levels of inflammatory biomarkers, interleukin 6 (IL-6) and C-reactive protein (CRP), measured at age 9.5 years. Outcome (depression in early adulthood) was the same as that in project 1. MIs were used to decrease bias due to loss-to-follow-up. Logistic regression models were constructed to prospectively investigate the relationship between IDP score and risk of depression with potential confounders adjusted. Analysis stratified by weight status was also conducted to further illustrate potential effect medication. In project 3, we utilized data from the UMatter Schenectady (UMS) project which focused on a multi-ethnic adult population in Schenectady, NY. Information, such as socio-demographic status, neighborhood environment, and diagnosed diabetes, was collected via the questionnaire. Scores for overall and three components of neighborhood walking environment (street conditions, crime safety, and traffic safety) were constructed. Depression symptoms were assessed via the Center for Epidemiologic Studies-Depression Scale (CES-D). Multilevel linear and logistic regression models were constructed to evaluate the relationship between neighborhood walking environment and depressive symptoms with potential individual-level socio-demographic and health behavioral confounders and neighborhood-level deprivation adjusted. We also evaluated the potential meditating effect and effect modification from diabetes. Results: Project 1 indicated that higher levels of parental involvement during childhood lowered the risk of developing depression in early adulthood. Parental involvement in school age (5-7 years) seems to be more influential on incident depression in young adulthood than parental involvement before the school age (0-4 years). Project 2 indicated that higher IDP score in childhood is associated with higher depression risk in early adulthood. Chronic inflammation may underlie the relationship between diet and depression even for children, especially those who are not overweight or obese. Project 3 indicated that among the racially diverse urban adult study population, better perceived neighborhood walking environment was associated with lower odds of depression. Diabetes does not mediate the association but may modify the association. Among participants with diabetes, better perception of neighborhood traffic safety while among participants without diabetes, better perceptions of neighborhood street conditions and crime safety contribute to reduced probability of having elevated depressive symptoms. Conclusion: To reduce current and future burden of depression, study findings add scientific evidence for (1) primary prevention interventions during childhood via increasing positive parent-child interactions and reducing unhealthy dietary intake and (2) improving neighborhood walking environment as a contextual support to promote better mental health among adults.

ISBN: 9780438817241Subjects--Topical Terms:

3168359
Health sciences.
Subjects--Index Terms:

Depression

Behavioral and Socio-Ecological Determinants of Depression at Different Stages of the Life Course.
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