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In silico methods for predicting dru...

Benfenati, Emilio.

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In silico methods for predicting drug toxicity /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	In silico methods for predicting drug toxicity // edited by Emilio Benfenati.
other author:	Benfenati, Emilio.
Published:	New York, NY :Humana Press, : 2022.,
Description:	xiv, 680 p. :ill. (some col.) ;27 cm.
Notes:	Previous edition: 2016.
[NT 15003449]:	QSAR Methods -- PBPK Modeling to Simulate the Fate of Compounds in Living Organisms -- Pharmacokinetic Tools and Applications -- In Silico Tools and Software to Predict ADMET of New Drug Candidates -- Development of In Silico Methods for Toxicity Prediction in Collaboration between Academia and the Pharmaceutical Industry -- Emerging Bioinformatics Methods and Resources in Drug Toxicology -- In Silico Prediction of Chemically-Induced Mutagenicity: A Weight of Evidence Approach Integrating Information from QSAR Models and Read-Across Predictions -- In Silico Methods for Chromosome Damage -- In Silico Methods for Carcinogenicity Assessment -- In Silico Models for Developmental Toxicity -- In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs -- In Silico Models for Predicting Acute Systemic Toxicity -- In Silico Models for Skin Sensitization and Irritation -- In Silico Models for Hepatotoxicity -- Machine Learning Models for Predicting Liver Toxicity -- Implementation of In Silico Toxicology Protocols in Leadscope -- Use of Lhasa Limited Products for the In Silico Prediction of Drug Toxicity -- Using VEGAHUB within a Weight-of-Evidence Strategy -- MultiCASE Platform for In Silico Toxicology -- Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing -- Use of In Silico Methods for the Regulatory Toxicological Assessment of Pharmaceutical Impurities -- Computational Modeling of Mixture Toxicity -- In Silico Methods for Ecological Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives -- Increasing the Value of Data within a Large Pharmaceutical Company through In Silico Models.
Subject:	Drugs - Laboratory manuals. - Toxicology -
ISBN:	9781071619599

In silico methods for predicting drug toxicity /
In silico methods for predicting drug toxicity /edited by Emilio Benfenati. - 2nd ed. - New York, NY :Humana Press,2022. - xiv, 680 p. :ill. (some col.) ;27 cm. - Methods in molecular biology,24251064-3745 ;. - Methods in molecular biology (Clifton, N.J.) ;v. 2425..

Previous edition: 2016.

Includes bibliographical references and index.

QSAR Methods -- PBPK Modeling to Simulate the Fate of Compounds in Living Organisms -- Pharmacokinetic Tools and Applications -- In Silico Tools and Software to Predict ADMET of New Drug Candidates -- Development of In Silico Methods for Toxicity Prediction in Collaboration between Academia and the Pharmaceutical Industry -- Emerging Bioinformatics Methods and Resources in Drug Toxicology -- In Silico Prediction of Chemically-Induced Mutagenicity: A Weight of Evidence Approach Integrating Information from QSAR Models and Read-Across Predictions -- In Silico Methods for Chromosome Damage -- In Silico Methods for Carcinogenicity Assessment -- In Silico Models for Developmental Toxicity -- In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs -- In Silico Models for Predicting Acute Systemic Toxicity -- In Silico Models for Skin Sensitization and Irritation -- In Silico Models for Hepatotoxicity -- Machine Learning Models for Predicting Liver Toxicity -- Implementation of In Silico Toxicology Protocols in Leadscope -- Use of Lhasa Limited Products for the In Silico Prediction of Drug Toxicity -- Using VEGAHUB within a Weight-of-Evidence Strategy -- MultiCASE Platform for In Silico Toxicology -- Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing -- Use of In Silico Methods for the Regulatory Toxicological Assessment of Pharmaceutical Impurities -- Computational Modeling of Mixture Toxicity -- In Silico Methods for Ecological Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives -- Increasing the Value of Data within a Large Pharmaceutical Company through In Silico Models.

This fully updated book explores all-new and revised protocols involving the use of in silico models, particularly with regard to pharmaceuticals. Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and implementation advice necessary for successful results. Authoritative and comprehensive, In Silico Methods for Predicting Drug Toxicity, Second Edition aims to guide the reader through the correct procedures needed to harness in silico models, a field which now touches a wide variety of research specialties.

ISBN: 9781071619599EUR219.99Subjects--Topical Terms:

3565836
Drugs
--Toxicology--Laboratory manuals.Index Terms--Genre/Form:

3565837
Laboratory manuals.

LC Class. No.: RM302.5 / .I56 2022

Dewey Class. No.: 615.190113

In silico methods for predicting drug toxicity /
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245 0 0 $a In silico methods for predicting drug toxicity / $c edited by Emilio Benfenati.
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300 $a xiv, 680 p. : $b ill. (some col.) ; $c 27 cm.
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504 $a Includes bibliographical references and index.
505 0 # $a QSAR Methods -- PBPK Modeling to Simulate the Fate of Compounds in Living Organisms -- Pharmacokinetic Tools and Applications -- In Silico Tools and Software to Predict ADMET of New Drug Candidates -- Development of In Silico Methods for Toxicity Prediction in Collaboration between Academia and the Pharmaceutical Industry -- Emerging Bioinformatics Methods and Resources in Drug Toxicology -- In Silico Prediction of Chemically-Induced Mutagenicity: A Weight of Evidence Approach Integrating Information from QSAR Models and Read-Across Predictions -- In Silico Methods for Chromosome Damage -- In Silico Methods for Carcinogenicity Assessment -- In Silico Models for Developmental Toxicity -- In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs -- In Silico Models for Predicting Acute Systemic Toxicity -- In Silico Models for Skin Sensitization and Irritation -- In Silico Models for Hepatotoxicity -- Machine Learning Models for Predicting Liver Toxicity -- Implementation of In Silico Toxicology Protocols in Leadscope -- Use of Lhasa Limited Products for the In Silico Prediction of Drug Toxicity -- Using VEGAHUB within a Weight-of-Evidence Strategy -- MultiCASE Platform for In Silico Toxicology -- Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing -- Use of In Silico Methods for the Regulatory Toxicological Assessment of Pharmaceutical Impurities -- Computational Modeling of Mixture Toxicity -- In Silico Methods for Ecological Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives -- Increasing the Value of Data within a Large Pharmaceutical Company through In Silico Models.
520 # $a This fully updated book explores all-new and revised protocols involving the use of in silico models, particularly with regard to pharmaceuticals. Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and implementation advice necessary for successful results. Authoritative and comprehensive, In Silico Methods for Predicting Drug Toxicity, Second Edition aims to guide the reader through the correct procedures needed to harness in silico models, a field which now touches a wide variety of research specialties.
650 # 0 $a Drugs $x Toxicology $v Laboratory manuals. $3 3565836
650 # 0 $a Drug development $x Computer simulation. $3 768310
650 # 0 $a Drugs $x Testing $x Computer simulation. $3 916012
650 # 7 $a Drugs $x Toxicology. $3 599073
655 # 7 $a Laboratory manuals. $2 fast $3 3565837
700 1 # $a Benfenati, Emilio. $3 813985
830 0 $a Methods in molecular biology (Clifton, N.J.) ; $v v. 2425. $3 3565835
830 0 $a Springer protocols (Series) $x 1949-2448 $3 3199413