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Dissipation and control in microscop...

Large, Steven J.

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Dissipation and control in microscopic nonequilibrium systems

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dissipation and control in microscopic nonequilibrium systems/ by Steven J. Large.
Author:	Large, Steven J.
Published:	Cham :Springer International Publishing : : 2021.,
Description:	xvii, 236 p. :ill., digital ;24 cm.
[NT 15003449]:	Chapter 1. Introduction -- Chapter 2. Theoretical background -- Chapter 3. DNA hairpins I: Calculating the generalized friction -- Chapter 4. DNA Hairpins II: reducing dissipation in nonequilibrium protocols -- Chapter 5. DNA Hairpins III: robustness, variability, and conclusions -- Chapter 6. Stochastic control in microscopic nonequilibrium systems -- Chapter 7. Optimal discrete control: minimizing dissipation in discretely driven systems -- Chapter 8. On dissipation bounds: discrete stochastic control of nonequilibrium systems -- Chapter 9. Free energy transduction within autonomous systems -- Chapter 10. Hidden excess power and autonomous Maxwell demons in strongly coupled nonequilibrium systems -- Chapter 11. Conclusions and outlook.
Contained By:	Springer Nature eBook
Subject:	Nonequilibrium statistical mechanics. -
Online resource:	https://doi.org/10.1007/978-3-030-85825-4
ISBN:	9783030858254

Dissipation and control in microscopic nonequilibrium systems
Large, Steven J.

Dissipation and control in microscopic nonequilibrium systems[electronic resource] /by Steven J. Large. - Cham :Springer International Publishing :2021. - xvii, 236 p. :ill., digital ;24 cm. - Springer theses,2190-5061. - Springer theses..

Chapter 1. Introduction -- Chapter 2. Theoretical background -- Chapter 3. DNA hairpins I: Calculating the generalized friction -- Chapter 4. DNA Hairpins II: reducing dissipation in nonequilibrium protocols -- Chapter 5. DNA Hairpins III: robustness, variability, and conclusions -- Chapter 6. Stochastic control in microscopic nonequilibrium systems -- Chapter 7. Optimal discrete control: minimizing dissipation in discretely driven systems -- Chapter 8. On dissipation bounds: discrete stochastic control of nonequilibrium systems -- Chapter 9. Free energy transduction within autonomous systems -- Chapter 10. Hidden excess power and autonomous Maxwell demons in strongly coupled nonequilibrium systems -- Chapter 11. Conclusions and outlook.

This thesis establishes a multifaceted extension of the deterministic control framework that has been a workhorse of nonequilibrium statistical mechanics, to stochastic, discrete, and autonomous control mechanisms. This facilitates the application of ideas from stochastic thermodynamics to the understanding of molecular machines in nanotechnology and in living things. It also gives a scale on which to evaluate the nonequilibrium energetic efficiency of molecular machines, guidelines for designing effective synthetic machines, and a perspective on the engineering principles that govern efficient microscopic energy transduction far from equilibrium. The thesis also documents the author's design, analysis, and interpretation of the first experimental demonstration of the utility of this generally applicable method for designing energetically-efficient control in biomolecules. Protocols designed using this framework systematically reduced dissipation, when compared to naive protocols, in DNA hairpins across a wide range of experimental unfolding speeds and between sequences with wildly different physical characteristics.

ISBN: 9783030858254

Standard No.: 10.1007/978-3-030-85825-4doiSubjects--Topical Terms:

741421
Nonequilibrium statistical mechanics.

LC Class. No.: QC174.86.N65 / L37 2021

Dewey Class. No.: 530.13

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505 0 $a Chapter 1. Introduction -- Chapter 2. Theoretical background -- Chapter 3. DNA hairpins I: Calculating the generalized friction -- Chapter 4. DNA Hairpins II: reducing dissipation in nonequilibrium protocols -- Chapter 5. DNA Hairpins III: robustness, variability, and conclusions -- Chapter 6. Stochastic control in microscopic nonequilibrium systems -- Chapter 7. Optimal discrete control: minimizing dissipation in discretely driven systems -- Chapter 8. On dissipation bounds: discrete stochastic control of nonequilibrium systems -- Chapter 9. Free energy transduction within autonomous systems -- Chapter 10. Hidden excess power and autonomous Maxwell demons in strongly coupled nonequilibrium systems -- Chapter 11. Conclusions and outlook.
520 $a This thesis establishes a multifaceted extension of the deterministic control framework that has been a workhorse of nonequilibrium statistical mechanics, to stochastic, discrete, and autonomous control mechanisms. This facilitates the application of ideas from stochastic thermodynamics to the understanding of molecular machines in nanotechnology and in living things. It also gives a scale on which to evaluate the nonequilibrium energetic efficiency of molecular machines, guidelines for designing effective synthetic machines, and a perspective on the engineering principles that govern efficient microscopic energy transduction far from equilibrium. The thesis also documents the author's design, analysis, and interpretation of the first experimental demonstration of the utility of this generally applicable method for designing energetically-efficient control in biomolecules. Protocols designed using this framework systematically reduced dissipation, when compared to naive protocols, in DNA hairpins across a wide range of experimental unfolding speeds and between sequences with wildly different physical characteristics.
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