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The hereditary basis of childhood cancer

Malkin, David.

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The hereditary basis of childhood cancer

Record Type:	Electronic resources : Monograph/item
Title/Author:	The hereditary basis of childhood cancer/ edited by David Malkin.
other author:	Malkin, David.
Published:	Cham :Springer International Publishing : : 2021.,
Description:	xi, 491 p. :ill., digital ;24 cm.
[NT 15003449]:	1: Li-Fraumeni Syndrome -- 2: Pediatric Central Nervous System Cancer Predisposition -- 3: Rhabdoid Tumors -- 4: Neurofibromatosis -- 5: Pheochromocytoma and Paraganglioma syndromes -- 6: Wilms tumor -- 7: Hereditary Overgrowth Syndromes -- 8: Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions -- 9: DICER1 Syndrome -- 10: Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes -- 11: Inherited Risk for Childhood Leukemia -- 12: Inherited pediatric cancer in low and intermediate resource countries -- 13: Frontline Ethico-legal Issues in Childhood Cancer Genetics Research -- 14: Genetic counseling and testing -- 15: Psychosocial aspects of childhood cancer genetics -- 16: Recognition of cancer predisposition syndromes.
Contained By:	Springer Nature eBook
Subject:	Cancer in children - Genetic aspects. -
Online resource:	https://doi.org/10.1007/978-3-030-74448-9
ISBN:	9783030744489

The hereditary basis of childhood cancer
The hereditary basis of childhood cancer[electronic resource] /edited by David Malkin. - Cham :Springer International Publishing :2021. - xi, 491 p. :ill., digital ;24 cm.

1: Li-Fraumeni Syndrome -- 2: Pediatric Central Nervous System Cancer Predisposition -- 3: Rhabdoid Tumors -- 4: Neurofibromatosis -- 5: Pheochromocytoma and Paraganglioma syndromes -- 6: Wilms tumor -- 7: Hereditary Overgrowth Syndromes -- 8: Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions -- 9: DICER1 Syndrome -- 10: Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes -- 11: Inherited Risk for Childhood Leukemia -- 12: Inherited pediatric cancer in low and intermediate resource countries -- 13: Frontline Ethico-legal Issues in Childhood Cancer Genetics Research -- 14: Genetic counseling and testing -- 15: Psychosocial aspects of childhood cancer genetics -- 16: Recognition of cancer predisposition syndromes.

This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the 'disease-related' chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where 'modern' technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.

ISBN: 9783030744489

Standard No.: 10.1007/978-3-030-74448-9doiSubjects--Topical Terms:

3513894
Cancer in children
--Genetic aspects.

LC Class. No.: RC281.C4

Dewey Class. No.: 618.92994

The hereditary basis of childhood cancer
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245 0 4 $a The hereditary basis of childhood cancer $h [electronic resource] / $c edited by David Malkin.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2021.
300 $a xi, 491 p. : $b ill., digital ; $c 24 cm.
505 0 $a 1: Li-Fraumeni Syndrome -- 2: Pediatric Central Nervous System Cancer Predisposition -- 3: Rhabdoid Tumors -- 4: Neurofibromatosis -- 5: Pheochromocytoma and Paraganglioma syndromes -- 6: Wilms tumor -- 7: Hereditary Overgrowth Syndromes -- 8: Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions -- 9: DICER1 Syndrome -- 10: Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes -- 11: Inherited Risk for Childhood Leukemia -- 12: Inherited pediatric cancer in low and intermediate resource countries -- 13: Frontline Ethico-legal Issues in Childhood Cancer Genetics Research -- 14: Genetic counseling and testing -- 15: Psychosocial aspects of childhood cancer genetics -- 16: Recognition of cancer predisposition syndromes.
520 $a This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the 'disease-related' chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where 'modern' technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.
650 0 $a Cancer in children $x Genetic aspects. $3 3513894
650 0 $a Cancer in children $x Molecular aspects. $3 3513895
650 1 4 $a Gene Expression. $3 600530
650 2 4 $a Human Genetics. $3 891169
650 2 4 $a Cancer Research. $3 891172
650 2 4 $a Pharmacology/Toxicology. $3 890953
700 1 $a Malkin, David. $3 3513893
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-3-030-74448-9
950 $a Biomedical and Life Sciences (SpringerNature-11642)