東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

HSF1 and molecular chaperones in bio...

Mendillo, Marc Laurence.

Linked to FindBook

Google Book

Amazon

博客來

HSF1 and molecular chaperones in biology and cancer

Record Type:	Electronic resources : Monograph/item
Title/Author:	HSF1 and molecular chaperones in biology and cancer/ edited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval.
other author:	Mendillo, Marc Laurence.
Published:	Cham :Springer International Publishing : : 2020.,
Description:	viii, 182 p. :ill. (some col.), digital ;24 cm.
[NT 15003449]:	Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks - redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.
Contained By:	Springer eBooks
Subject:	Molecular chaperones. -
Online resource:	https://doi.org/10.1007/978-3-030-40204-4
ISBN:	9783030402044

HSF1 and molecular chaperones in biology and cancer
HSF1 and molecular chaperones in biology and cancer[electronic resource] /edited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval. - Cham :Springer International Publishing :2020. - viii, 182 p. :ill. (some col.), digital ;24 cm. - Advances in experimental medicine and biology,v.12430065-2598 ;. - Advances in experimental medicine and biology ;v.1243..

Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks - redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.

Protein homeostasis, or "Proteostasis", lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease.

ISBN: 9783030402044

Standard No.: 10.1007/978-3-030-40204-4doiSubjects--Topical Terms:

816775
Molecular chaperones.

LC Class. No.: QP552.M64 / H743 2020

Dewey Class. No.: 572.633

HSF1 and molecular chaperones in biology and cancer
LDR:03517nmm a2200337 a 4500 001 2217517
003 DE-He213
005 20200810170756.0
006 m d
007 cr nn 008maaau
008 201120s2020 sz s 0 eng d
020 $a 9783030402044 $q (electronic bk.)
020 $a 9783030402037 $q (paper)
024 7 $a 10.1007/978-3-030-40204-4 $2 doi
035 $a 978-3-030-40204-4
040 $a GP $c GP
041 0 $a eng
050 4 $a QP552.M64 $b H743 2020
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
072 7 $a MFN $2 thema
082 0 4 $a 572.633 $2 23
090 $a QP552.M64 $b H873 2020
245 0 0 $a HSF1 and molecular chaperones in biology and cancer $h [electronic resource] / $c edited by Marc Laurence Mendillo, David Pincus, Ruth Scherz-Shouval.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2020.
300 $a viii, 182 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v v.1243
505 0 $a Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks - redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.
520 $a Protein homeostasis, or "Proteostasis", lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease.
650 0 $a Molecular chaperones. $3 816775
650 1 4 $a Human Genetics. $3 891169
650 2 4 $a Cancer Research. $3 891172
650 2 4 $a Molecular Medicine. $3 890952
650 2 4 $a Proteomics. $3 600542
650 2 4 $a Protein Science. $3 1067276
650 2 4 $a Protein Structure. $3 1006100
700 1 $a Mendillo, Marc Laurence. $3 3450794
700 1 $a Pincus, David. $3 3450795
700 1 $a Scherz-Shouval, Ruth. $3 3450796
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a Advances in experimental medicine and biology ; $v v.1243. $3 3450797
856 4 0 $u https://doi.org/10.1007/978-3-030-40204-4
950 $a Biomedical and Life Sciences (Springer-11642)