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Chemical epigenetics

Mai, Antonello.

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Chemical epigenetics

Record Type:	Electronic resources : Monograph/item
Title/Author:	Chemical epigenetics/ edited by Antonello Mai.
other author:	Mai, Antonello.
Published:	Cham :Springer International Publishing : : 2020.,
Description:	ix, 567 p. :ill., digital ;24 cm.
[NT 15003449]:	Targeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery -- Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases -- Sirtuin Inhibitors and Activators -- Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors -- Lysine Methyltransferases and Their Inhibitors -- PRMT Inhibitors -- Lysine-Specific Histone Demethylases 1/2 (LSD1/2) and Their Inhibitors -- Inhibitors of JmjC-Containing Histone Demethylases -- Chemical Compounds Targeting DNA Methylation and Hydroxymethylation -- Applied Biophysics for Bromodomain Drug Discovery -- Methyl-Readers and Inhibitors -- Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets? - Acetylation and Methylation in Asthma, COPD, and Lung Cancer -- Structure-Based Design ofEpigenetic Inhibitors -- Experimental Methodologies for Detection and Mapping of Epigenetic DNA Marks -- Advanced Assays in Epigenetics.
Contained By:	Springer eBooks
Subject:	Chemogenomics. -
Online resource:	https://doi.org/10.1007/978-3-030-42982-9
ISBN:	9783030429829

Chemical epigenetics
Chemical epigenetics[electronic resource] /edited by Antonello Mai. - Cham :Springer International Publishing :2020. - ix, 567 p. :ill., digital ;24 cm. - Topics in medicinal chemistry,331862-2461 ;. - Topics in medicinal chemistry ;33..

Targeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery -- Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases -- Sirtuin Inhibitors and Activators -- Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors -- Lysine Methyltransferases and Their Inhibitors -- PRMT Inhibitors -- Lysine-Specific Histone Demethylases 1/2 (LSD1/2) and Their Inhibitors -- Inhibitors of JmjC-Containing Histone Demethylases -- Chemical Compounds Targeting DNA Methylation and Hydroxymethylation -- Applied Biophysics for Bromodomain Drug Discovery -- Methyl-Readers and Inhibitors -- Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets? - Acetylation and Methylation in Asthma, COPD, and Lung Cancer -- Structure-Based Design ofEpigenetic Inhibitors -- Experimental Methodologies for Detection and Mapping of Epigenetic DNA Marks -- Advanced Assays in Epigenetics.

This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.

ISBN: 9783030429829

Standard No.: 10.1007/978-3-030-42982-9doiSubjects--Topical Terms:

3231947
Chemogenomics.

LC Class. No.: QH438.4.C45 / C446 2020

Dewey Class. No.: 615.7

Chemical epigenetics
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245 0 0 $a Chemical epigenetics $h [electronic resource] / $c edited by Antonello Mai.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2020.
300 $a ix, 567 p. : $b ill., digital ; $c 24 cm.
490 1 $a Topics in medicinal chemistry, $x 1862-2461 ; $v 33
505 0 $a Targeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery -- Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases -- Sirtuin Inhibitors and Activators -- Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors -- Lysine Methyltransferases and Their Inhibitors -- PRMT Inhibitors -- Lysine-Specific Histone Demethylases 1/2 (LSD1/2) and Their Inhibitors -- Inhibitors of JmjC-Containing Histone Demethylases -- Chemical Compounds Targeting DNA Methylation and Hydroxymethylation -- Applied Biophysics for Bromodomain Drug Discovery -- Methyl-Readers and Inhibitors -- Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets? - Acetylation and Methylation in Asthma, COPD, and Lung Cancer -- Structure-Based Design ofEpigenetic Inhibitors -- Experimental Methodologies for Detection and Mapping of Epigenetic DNA Marks -- Advanced Assays in Epigenetics.
520 $a This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.
650 0 $a Chemogenomics. $3 3231947
650 0 $a Epigenetics. $3 1568224
650 1 4 $a Medicinal Chemistry. $3 892420
650 2 4 $a Genetics and Genomics. $3 3385208
650 2 4 $a Enzymology. $3 540241
650 2 4 $a Industrial Chemistry/Chemical Engineering. $3 890826
700 1 $a Mai, Antonello. $3 3449532
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a Topics in medicinal chemistry ; $v 33. $3 3449533
856 4 0 $u https://doi.org/10.1007/978-3-030-42982-9
950 $a Chemistry and Materials Science (Springer-11644)