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Characterization of Degradation Prof...

Chen, Naihan.

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Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation./
Author:	Chen, Naihan.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	252 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
Contained By:	Dissertations Abstracts International80-12B.
Subject:	Pharmaceutical sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10935214
ISBN:	9781392199411

Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation.
Chen, Naihan.

Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 252 p.

Source: Dissertations Abstracts International, Volume: 80-12, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.

This item must not be sold to any third party vendors.

Immune modulation has been widely explored as a robust tool given the essential role played by the immune system at establishing host defense. Immune responses can be up or down regulated in a specific manner to prevent and/or treat various diseases. Vaccination and autoimmune disease treatment represent two arms of immunomodulation applications, with vaccination prophylactically boosting host immunity against a specific antigen, while autoimmune treatments suppress the immune system to achieve therapeutic effect. This thesis aims to characterize and optimize vaccination and autoimmune disease treatment using a polymeric particulate delivery platform. Despite general success of vaccine and autoimmune therapy, both processes can be improved and optimized. For vaccines, poor immunogenicity of subunit vaccines often requires delivery vehicles for substantial protection. However, limited control over delivery profiles is available with current platforms. Due to significant impact of precise control over delivery kinetics on immune activation profiles, an enhanced delivery platform with flexible tunability in cargo delivery is in great need. For autoimmune treatment, although general immune suppression alleviates disease symptoms, severe adverse side effects that result from blanket inhibition call for alternative approaches. While researchers have started to explore antigen-specific therapies, options are limited and often with substantial cost or little flexibility. Work outlined in this thesis demonstrates how acetalated dextran (Ace-DEX) particles can be applied to characterize and optimize vaccination profiles and improve autoimmune treatment outcome. By offering tunable delivery profiles, generating robust protection after vaccination, and developing potent and specific immune suppression for autoimmune treatment, the Ace-DEX delivery system improves safety and efficacy of vaccines and autoimmune treatment, contributing to better immune modulation therapies.

ISBN: 9781392199411Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Characterization of Degradation Profiles of Acetalated Dextran Microparticles and Their Application for Immune Modulation.
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