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Understanding Multiscale Release Beh...

Marquetti, Izabele.

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Understanding Multiscale Release Behavior of Biomolecules for Tissue Engineering Applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Understanding Multiscale Release Behavior of Biomolecules for Tissue Engineering Applications./
Author:	Marquetti, Izabele.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	140 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
Contained By:	Dissertations Abstracts International80-12B.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13811619
ISBN:	9781392196403

Understanding Multiscale Release Behavior of Biomolecules for Tissue Engineering Applications.
Marquetti, Izabele.

Understanding Multiscale Release Behavior of Biomolecules for Tissue Engineering Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 140 p.

Source: Dissertations Abstracts International, Volume: 80-12, Section: B.

Thesis (Ph.D.)--North Carolina Agricultural and Technical State University, 2019.

This item must not be sold to any third party vendors.

Bone morphogenetic proteins (BMPs) are growth factors associated with different development functions in regenerative medicine and tissue engineering. BMP-2 is a type of bone morphogenetic proteins that has favorable properties to the development of bone and cartilage tissue, including osteoblast differentiation and proliferation, helping to increase the biocompatibility of medical implants. However, growth factors are usually unstable in the tissue environment which makes it difficult to be applied as a clinical therapy. This study aims to analyze significant properties of BMP-2 that contribute to the repair of bone and cartilage tissues for tissue engineering applications. In this research, molecular dynamics simulations were performed to analyze the behavior of BMP-2 under different environmental conditions. Adsorption, stabilization and folding/unfolding of the protein and its interaction with biomaterials was studied to define the best conditions to limit protein diffusion and maximize tissue regeneration. Water and saline solution were used as a dissolution media for the solvation of the biomolecule to mimic cellular environment. The effect of temperature on the protein adsorption was studied; room temperature (293 K), in vivo conditions (310 K), and boiling point of water (373 K) were considered. Simulations were performed using the Nanoscale Molecular Dynamics (NAMD) software and Virtual Molecular Dynamics (VMD) platform to build the molecular model. Substrate materials with medical relevance including gold, silicon nitride, graphite, and silicon dioxide were used in the simulations. The investigation of BMP-2 protein interaction under different physiological conditions reveals the complex biochemical cues for tissue engineering applications. This research contributes to the field of tissue engineering and regenerative medicine since growth factors have a crucial role on the signaling and activation of tissue development.

ISBN: 9781392196403Subjects--Topical Terms:

535387
Biomedical engineering.

Understanding Multiscale Release Behavior of Biomolecules for Tissue Engineering Applications.
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520 $a Bone morphogenetic proteins (BMPs) are growth factors associated with different development functions in regenerative medicine and tissue engineering. BMP-2 is a type of bone morphogenetic proteins that has favorable properties to the development of bone and cartilage tissue, including osteoblast differentiation and proliferation, helping to increase the biocompatibility of medical implants. However, growth factors are usually unstable in the tissue environment which makes it difficult to be applied as a clinical therapy. This study aims to analyze significant properties of BMP-2 that contribute to the repair of bone and cartilage tissues for tissue engineering applications. In this research, molecular dynamics simulations were performed to analyze the behavior of BMP-2 under different environmental conditions. Adsorption, stabilization and folding/unfolding of the protein and its interaction with biomaterials was studied to define the best conditions to limit protein diffusion and maximize tissue regeneration. Water and saline solution were used as a dissolution media for the solvation of the biomolecule to mimic cellular environment. The effect of temperature on the protein adsorption was studied; room temperature (293 K), in vivo conditions (310 K), and boiling point of water (373 K) were considered. Simulations were performed using the Nanoscale Molecular Dynamics (NAMD) software and Virtual Molecular Dynamics (VMD) platform to build the molecular model. Substrate materials with medical relevance including gold, silicon nitride, graphite, and silicon dioxide were used in the simulations. The investigation of BMP-2 protein interaction under different physiological conditions reveals the complex biochemical cues for tissue engineering applications. This research contributes to the field of tissue engineering and regenerative medicine since growth factors have a crucial role on the signaling and activation of tissue development.
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