東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Reprogramming and Modeling Glial Enc...

Winter, Bailey.

FindBook

Google Book

Amazon

博客來

Reprogramming and Modeling Glial Encapsulation Surrounding Implanted Electrodes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Reprogramming and Modeling Glial Encapsulation Surrounding Implanted Electrodes./
作者:	Winter, Bailey.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	76 p.
附註:	Source: Masters Abstracts International, Volume: 80-11.
Contained By:	Masters Abstracts International80-11.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13877935
ISBN:	9781392120781

Reprogramming and Modeling Glial Encapsulation Surrounding Implanted Electrodes.
Winter, Bailey.

Reprogramming and Modeling Glial Encapsulation Surrounding Implanted Electrodes. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 76 p.

Source: Masters Abstracts International, Volume: 80-11.

Thesis (M.S.)--Michigan State University, 2019.

This item must not be sold to any third party vendors.

Implanted microelectrode arrays are increasingly popular tools to study neural function and structure and show great promise as treatments for neurological disorders. However, these devices, especially those designed to record neural activity, often fail over time. The loss of neurons at the device-tissue interface during the reactive immune response to implantation is thought to contribute to device failure, however, the exact mechanisms are not well understood. In this thesis, I explore means of restoring the neuronal population through the direct reprogramming of astrocytes using viral vectors in vitro. To apply these findings to implanted microelectrodes, vectors need to be delivered to the interfacial region. To address this, a method, detailed in this thesis, has been developed to deliver vectors using microfluidic devices. Finally, the frame work for an in vitro model of the foreign body response has been constructed, with the intention of using this model to further explore the molecular pathways that are critical for propagating the foreign body response, contributing to neuronal loss, and ultimately causing device failure.

ISBN: 9781392120781Subjects--Topical Terms:

588700
Neurosciences.

Reprogramming and Modeling Glial Encapsulation Surrounding Implanted Electrodes.
LDR:02218nmm a2200337 4500 001 2208899
005 20191025102438.5
008 201008s2019 ||||||||||||||||| ||eng d
020 $a 9781392120781
035 $a (MiAaPQ)AAI13877935
035 $a (MiAaPQ)grad.msu:16776
035 $a AAI13877935
040 $a MiAaPQ $c MiAaPQ
100 1 $a Winter, Bailey. $3 3435965
245 1 0 $a Reprogramming and Modeling Glial Encapsulation Surrounding Implanted Electrodes.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 76 p.
500 $a Source: Masters Abstracts International, Volume: 80-11.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Purcell, Erin.
502 $a Thesis (M.S.)--Michigan State University, 2019.
506 $a This item must not be sold to any third party vendors.
520 $a Implanted microelectrode arrays are increasingly popular tools to study neural function and structure and show great promise as treatments for neurological disorders. However, these devices, especially those designed to record neural activity, often fail over time. The loss of neurons at the device-tissue interface during the reactive immune response to implantation is thought to contribute to device failure, however, the exact mechanisms are not well understood. In this thesis, I explore means of restoring the neuronal population through the direct reprogramming of astrocytes using viral vectors in vitro. To apply these findings to implanted microelectrodes, vectors need to be delivered to the interfacial region. To address this, a method, detailed in this thesis, has been developed to deliver vectors using microfluidic devices. Finally, the frame work for an in vitro model of the foreign body response has been constructed, with the intention of using this model to further explore the molecular pathways that are critical for propagating the foreign body response, contributing to neuronal loss, and ultimately causing device failure.
590 $a School code: 0128.
650 4 $a Neurosciences. $3 588700
650 4 $a Biomedical engineering. $3 535387
650 4 $a Physiology. $3 518431
690 $a 0317
690 $a 0541
690 $a 0719
710 2 $a Michigan State University. $b Biomedical Engineering. $3 3435966
773 0 $t Masters Abstracts International $g 80-11.
790 $a 0128
791 $a M.S.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13877935