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The Role of Human Cytomegalovirus Pr...

Rak, Michael.

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The Role of Human Cytomegalovirus Protein UL135 in Virus Replication, Latency, and Reactivation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Role of Human Cytomegalovirus Protein UL135 in Virus Replication, Latency, and Reactivation./
Author:	Rak, Michael.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	160 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-03, Section: B.
Contained By:	Dissertations Abstracts International80-03B.
Subject:	Molecular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10846704
ISBN:	9780438346543

The Role of Human Cytomegalovirus Protein UL135 in Virus Replication, Latency, and Reactivation.
Rak, Michael.

The Role of Human Cytomegalovirus Protein UL135 in Virus Replication, Latency, and Reactivation. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 160 p.

Source: Dissertations Abstracts International, Volume: 80-03, Section: B.

Thesis (Ph.D.)--The University of Arizona, 2018.

This item must not be sold to any third party vendors.

Human cytomegalovirus (CMV) is a ubiquitous herpesvirus that infects the majority of the world's population. CMV can establish a latent infection, enabling the lifelong persistence of CMV infection and effectively evading the immune system and antiviral drugs. We have characterized the protein product of UL135 (pUL135), and discovered that pUL135 drives viral replication and is necessary for viral reactivation from latency, counteracting the latency-promoting effects of another CMV protein, pUL138. The functions of pUL135 and pUL138 proteins are antagonistic, epistatically linked, and the balance between pUL135 and pUL138 regulates viral infection and latency. Through the use of proteomic screens, we have identified and disrupted interactions of pUL135 with cellular proteins Abi-1 and CIN85; we discovered that interactions are necessary for viral reactivation from latency. pUL135 and its interactions with Abi-1 and CIN85 influence the levels of EGFR on the cell and alter the dynamics of EGFR trafficking within the cell. This work investigates the various roles and mechanisms by which UL135 serves as a mediator of CMV infection.

ISBN: 9780438346543Subjects--Topical Terms:

517296
Molecular biology.

The Role of Human Cytomegalovirus Protein UL135 in Virus Replication, Latency, and Reactivation.
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245 1 4 $a The Role of Human Cytomegalovirus Protein UL135 in Virus Replication, Latency, and Reactivation.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 160 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-03, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Goodrum, Felicia D.
502 $a Thesis (Ph.D.)--The University of Arizona, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Human cytomegalovirus (CMV) is a ubiquitous herpesvirus that infects the majority of the world's population. CMV can establish a latent infection, enabling the lifelong persistence of CMV infection and effectively evading the immune system and antiviral drugs. We have characterized the protein product of UL135 (pUL135), and discovered that pUL135 drives viral replication and is necessary for viral reactivation from latency, counteracting the latency-promoting effects of another CMV protein, pUL138. The functions of pUL135 and pUL138 proteins are antagonistic, epistatically linked, and the balance between pUL135 and pUL138 regulates viral infection and latency. Through the use of proteomic screens, we have identified and disrupted interactions of pUL135 with cellular proteins Abi-1 and CIN85; we discovered that interactions are necessary for viral reactivation from latency. pUL135 and its interactions with Abi-1 and CIN85 influence the levels of EGFR on the cell and alter the dynamics of EGFR trafficking within the cell. This work investigates the various roles and mechanisms by which UL135 serves as a mediator of CMV infection.
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650 4 $a Cellular biology. $3 3172791
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10846704