東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Treatment of Liver Metastasis Via Na...

Goodwin, Tyler Jay.

Linked to FindBook

Google Book

Amazon

博客來

Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes./
Author:	Goodwin, Tyler Jay.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	145 p.
Notes:	Source: Dissertations Abstracts International, Volume: 79-01, Section: B.
Contained By:	Dissertations Abstracts International79-01B.
Subject:	Nanoscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10258608
ISBN:	9781369871494

Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes.
Goodwin, Tyler Jay.

Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 145 p.

Source: Dissertations Abstracts International, Volume: 79-01, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2017.

This item is not available from ProQuest Dissertations & Theses.

Recent developments in the field of immunology, gene therapy and nanotechnology have brought new tactics to treat cancers and other acute diseases. Traditional strategies for cancer treatment relies on systemic administration of toxic small molecules. This strategy has been successful in some cancer types, but many cancers return or gain resistance, leaving the patient with a suppressed immune system due to the off-target toxicities from the chemotherapy. Therefore, more elaborate strategies are now being developed to avoid the off-target toxicities, while strengthening the patient's immune response against these cancers. Several of these promising immune boosting therapeutics have now reached the clinic as antibody drugs or cancer vaccines. However, these antibody drugs are still showing signs of off-target toxicities due to the systemic administration. This dissertation research focuses on understanding the basic microenvironment of liver metastasis, the role immune signaling cytokines and chemokines play in the progression of this disease and recruitment of the immune cell populations, as well as investigate the ability to manipulate these immune signals to shift to an anti-tumor microenvironment following nanoparticle gene delivery of a novel Trap technology. The tumor immune microenvironment as well as strategies to modulate the environment will be summarized and discussed in detail. (Abstract shortened by ProQuest.).

ISBN: 9781369871494Subjects--Topical Terms:

587832
Nanoscience.

Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes.
LDR:02724nmm a2200349 4500 001 2207462
005 20190920131230.5
008 201008s2017 ||||||||||||||||| ||eng d
020 $a 9781369871494
035 $a (MiAaPQ)AAI10258608
035 $a (MiAaPQ)unc:16729
035 $a AAI10258608
040 $a MiAaPQ $c MiAaPQ
100 1 $a Goodwin, Tyler Jay. $3 3434450
245 1 0 $a Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 145 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-01, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Huang, Leaf;Smith, Philip C.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2017.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a Recent developments in the field of immunology, gene therapy and nanotechnology have brought new tactics to treat cancers and other acute diseases. Traditional strategies for cancer treatment relies on systemic administration of toxic small molecules. This strategy has been successful in some cancer types, but many cancers return or gain resistance, leaving the patient with a suppressed immune system due to the off-target toxicities from the chemotherapy. Therefore, more elaborate strategies are now being developed to avoid the off-target toxicities, while strengthening the patient's immune response against these cancers. Several of these promising immune boosting therapeutics have now reached the clinic as antibody drugs or cancer vaccines. However, these antibody drugs are still showing signs of off-target toxicities due to the systemic administration. This dissertation research focuses on understanding the basic microenvironment of liver metastasis, the role immune signaling cytokines and chemokines play in the progression of this disease and recruitment of the immune cell populations, as well as investigate the ability to manipulate these immune signals to shift to an anti-tumor microenvironment following nanoparticle gene delivery of a novel Trap technology. The tumor immune microenvironment as well as strategies to modulate the environment will be summarized and discussed in detail. (Abstract shortened by ProQuest.).
590 $a School code: 0153.
650 4 $a Nanoscience. $3 587832
650 4 $a Pharmacy sciences. $3 3174369
650 4 $a Nanotechnology. $3 526235
690 $a 0565
690 $a 0572
690 $a 0652
710 2 $a The University of North Carolina at Chapel Hill. $b Pharmaceutical Sciences. $3 1285238
773 0 $t Dissertations Abstracts International $g 79-01B.
790 $a 0153
791 $a Ph.D.
792 $a 2017
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10258608