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Medullary Astrocytes May Modulate th...

Pun, Henry.

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Medullary Astrocytes May Modulate the Depressed Excitability of Rat Face Primary Motor Cortex (Face-M1) Induced by Noxious Tooth Pulp Stimulation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Medullary Astrocytes May Modulate the Depressed Excitability of Rat Face Primary Motor Cortex (Face-M1) Induced by Noxious Tooth Pulp Stimulation./
Author:	Pun, Henry.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2014,
Description:	113 p.
Notes:	Source: Masters Abstracts International, Volume: 76-08.
Contained By:	Masters Abstracts International76-08.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1572309
ISBN:	9781321464474

Medullary Astrocytes May Modulate the Depressed Excitability of Rat Face Primary Motor Cortex (Face-M1) Induced by Noxious Tooth Pulp Stimulation.
Pun, Henry.

Medullary Astrocytes May Modulate the Depressed Excitability of Rat Face Primary Motor Cortex (Face-M1) Induced by Noxious Tooth Pulp Stimulation. - Ann Arbor : ProQuest Dissertations & Theses, 2014 - 113 p.

Source: Masters Abstracts International, Volume: 76-08.

Thesis (M.Sc.)--University of Toronto (Canada), 2014.

This item must not be sold to any third party vendors.

Acute inflammatory dental pain is a prevalent pain condition that is often associated with disruption of orofacial sensorimotor functions. The aims of this project were to examine whether application of the inflammatory irritant mustard oil (MO) to the rat maxillary molar tooth pulp affects face-M1 excitability manifested as a change in intracortical microstimulation threshold intensity for evoking jaw-opening muscle electromyographic activity, and if subsequent application of the astrocytic inhibitor methionine sulfoximine (MSO) to the medullary dorsal horn (MDH) can modulate the MO-induced effects. Compared with vehicle, pulpal MO application significantly decreased face-M1 excitability. Subsequent MSO application to the MDH attenuated the MO-induced effects. These novel findings suggest that acute noxious stimulation of the dental pulp is associated with decreased face-M1 excitability that may be, in part, dependent on the functional integrity of MDH astrocytes. Therefore, cortical and subcortical mechanisms may contribute to limit jaw movements in acute inflammatory dental pain.

ISBN: 9781321464474Subjects--Topical Terms:

588700
Neurosciences.

Medullary Astrocytes May Modulate the Depressed Excitability of Rat Face Primary Motor Cortex (Face-M1) Induced by Noxious Tooth Pulp Stimulation.
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500 $a Publisher info.: Dissertation/Thesis.
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502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2014.
506 $a This item must not be sold to any third party vendors.
520 $a Acute inflammatory dental pain is a prevalent pain condition that is often associated with disruption of orofacial sensorimotor functions. The aims of this project were to examine whether application of the inflammatory irritant mustard oil (MO) to the rat maxillary molar tooth pulp affects face-M1 excitability manifested as a change in intracortical microstimulation threshold intensity for evoking jaw-opening muscle electromyographic activity, and if subsequent application of the astrocytic inhibitor methionine sulfoximine (MSO) to the medullary dorsal horn (MDH) can modulate the MO-induced effects. Compared with vehicle, pulpal MO application significantly decreased face-M1 excitability. Subsequent MSO application to the MDH attenuated the MO-induced effects. These novel findings suggest that acute noxious stimulation of the dental pulp is associated with decreased face-M1 excitability that may be, in part, dependent on the functional integrity of MDH astrocytes. Therefore, cortical and subcortical mechanisms may contribute to limit jaw movements in acute inflammatory dental pain.
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