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Phase Resolved Optical Coherence Tom...

Tong, Minh Quang.

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Phase Resolved Optical Coherence Tomography for Label-free Detection of Neural Activity.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Phase Resolved Optical Coherence Tomography for Label-free Detection of Neural Activity./
Author:	Tong, Minh Quang.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	85 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-09, Section: B.
Contained By:	Dissertations Abstracts International80-09B.
Subject:	Bioengineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10981953
ISBN:	9780438897298

Phase Resolved Optical Coherence Tomography for Label-free Detection of Neural Activity.
Tong, Minh Quang.

Phase Resolved Optical Coherence Tomography for Label-free Detection of Neural Activity. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 85 p.

Source: Dissertations Abstracts International, Volume: 80-09, Section: B.

Thesis (Ph.D.)--University of California, Riverside, 2018.

This item must not be sold to any third party vendors.

Current methods for detection of nervous system activity have been limited to electrophysiology, which requires the electrode to contact the nervous system or optical-based techniques that require incorporation of reporter agents. Both methods are golden standards but have limitations. Optical coherence tomography (OCT) is an imaging technique based on light that measures intrinsic structural changes associated with an action potential. A benefit of using OCT is that it does not require any exogenous agents and is minimally invasive. Phase-resolved OCT detects 1-30 nm swelling of an axon during neural activity. In my studies described here, phase-resolved OCT was used to detect the swelling Drosophila neurons when presented with ecdysis triggering hormone as well as a 1-3 nm swelling of a cockroach axon caused by action. However, since phase imaging is limited to one point, the dissertation ends with development of the line field swept source OCT system that can provide images of a b-line or cross-sectional image without using a scanning device.

ISBN: 9780438897298Subjects--Topical Terms:

657580
Bioengineering.

Phase Resolved Optical Coherence Tomography for Label-free Detection of Neural Activity.
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245 1 0 $a Phase Resolved Optical Coherence Tomography for Label-free Detection of Neural Activity.
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300 $a 85 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-09, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Park, Hyle;Adams, Micheal.
502 $a Thesis (Ph.D.)--University of California, Riverside, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Current methods for detection of nervous system activity have been limited to electrophysiology, which requires the electrode to contact the nervous system or optical-based techniques that require incorporation of reporter agents. Both methods are golden standards but have limitations. Optical coherence tomography (OCT) is an imaging technique based on light that measures intrinsic structural changes associated with an action potential. A benefit of using OCT is that it does not require any exogenous agents and is minimally invasive. Phase-resolved OCT detects 1-30 nm swelling of an axon during neural activity. In my studies described here, phase-resolved OCT was used to detect the swelling Drosophila neurons when presented with ecdysis triggering hormone as well as a 1-3 nm swelling of a cockroach axon caused by action. However, since phase imaging is limited to one point, the dissertation ends with development of the line field swept source OCT system that can provide images of a b-line or cross-sectional image without using a scanning device.
590 $a School code: 0032.
650 4 $a Bioengineering. $3 657580
650 4 $a Neurosciences. $3 588700
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710 2 $a University of California, Riverside. $b Neuroscience. $3 3434204
773 0 $t Dissertations Abstracts International $g 80-09B.
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10981953