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Assessment of Melanocyte-Specific Pr...

Falcon, Daniel Morales.

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Assessment of Melanocyte-Specific Primary and Memory Autoimmune Responses in Vitiligo- Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Assessment of Melanocyte-Specific Primary and Memory Autoimmune Responses in Vitiligo- Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens./
作者:	Falcon, Daniel Morales.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	186 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-02, Section: B.
Contained By:	Dissertations Abstracts International80-02B.
標題:	Cellular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10846064
ISBN:	9780438281141

Assessment of Melanocyte-Specific Primary and Memory Autoimmune Responses in Vitiligo- Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens.
Falcon, Daniel Morales.

Assessment of Melanocyte-Specific Primary and Memory Autoimmune Responses in Vitiligo- Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 186 p.

Source: Dissertations Abstracts International, Volume: 80-02, Section: B.

Thesis (Ph.D.)--University of Arkansas, 2018.

This item must not be sold to any third party vendors.

Vitiligo is an acquired de-pigmentation disorder characterized by the post-natal loss of epidermal melanocytes (pigment-producing cells) resulting in the appearance of white patches in the skin. The Smyth line of chicken is the only model for vitiligo that shares all the characteristics of the human condition including: spontaneous post-natal loss of melanocytes, interactions between genetic, environmental and immunological factors and associations with other autoimmune diseases. In addition, an avian model for vitiligo has the added benefit of an easily accessible target tissue (a growing feather) that allows for the repeated sampling of an individual and thus the continuous monitoring of local immune responses over time. Here, we sought to gain a comprehensive understanding of the initiating events leading to expression of vitiligo in growing feathers by monitoring the infiltration of leukocytes and concurrent immunological activities beginning prior-to visual onset and continuing throughout disease development. Furthermore, we examined the nature of the melanocyte-specific recall (i.e. memory) response by re-introducing the target cell (melanocyte) into the target tissue (growing feather) of completely depigmented Smyth chickens via intradermal injection. Lastly, we sought to gain insights into the role of melanocytes in provoking the autoimmune response by measuring the expression of co-stimulatory molecules in the presence of oxidative stress-inducing H2O2. During the primary response we observed characteristic rises in infiltrating B and αβ T cells as well as evidence of active recruitment and cell-mediated immune activities leading up to visual onset. Examination of growing feathers from vitiligo-susceptible Brown line chickens revealed novel anti-inflammatory immune activities which may be responsible for preventing vitiligo. We also observed characteristic memory-like increases in B and T cells as well as increases in recruitment and cell-mediated immune activities in response to injection of melanocytes into growing feathers of completely depigmented Smyth chickens. Lastly, we observed increased expression of CD40 and B7-1 in melanocytes derived from growing feathers of Smyth chickens treated with H2O2. Collectively, these results further support the notion of cell-mediated immune destruction of melanocytes in growing feathers. Furthermore, these data open new avenues of study in the vitiligo-prone Smyth line and vitiligo-susceptible Brown line chickens.

ISBN: 9780438281141Subjects--Topical Terms:

3172791
Cellular biology.

Assessment of Melanocyte-Specific Primary and Memory Autoimmune Responses in Vitiligo- Prone Smyth and Vitiligo-Susceptible, Non-Expressing Brown Line Chickens.
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520 $a Vitiligo is an acquired de-pigmentation disorder characterized by the post-natal loss of epidermal melanocytes (pigment-producing cells) resulting in the appearance of white patches in the skin. The Smyth line of chicken is the only model for vitiligo that shares all the characteristics of the human condition including: spontaneous post-natal loss of melanocytes, interactions between genetic, environmental and immunological factors and associations with other autoimmune diseases. In addition, an avian model for vitiligo has the added benefit of an easily accessible target tissue (a growing feather) that allows for the repeated sampling of an individual and thus the continuous monitoring of local immune responses over time. Here, we sought to gain a comprehensive understanding of the initiating events leading to expression of vitiligo in growing feathers by monitoring the infiltration of leukocytes and concurrent immunological activities beginning prior-to visual onset and continuing throughout disease development. Furthermore, we examined the nature of the melanocyte-specific recall (i.e. memory) response by re-introducing the target cell (melanocyte) into the target tissue (growing feather) of completely depigmented Smyth chickens via intradermal injection. Lastly, we sought to gain insights into the role of melanocytes in provoking the autoimmune response by measuring the expression of co-stimulatory molecules in the presence of oxidative stress-inducing H2O2. During the primary response we observed characteristic rises in infiltrating B and αβ T cells as well as evidence of active recruitment and cell-mediated immune activities leading up to visual onset. Examination of growing feathers from vitiligo-susceptible Brown line chickens revealed novel anti-inflammatory immune activities which may be responsible for preventing vitiligo. We also observed characteristic memory-like increases in B and T cells as well as increases in recruitment and cell-mediated immune activities in response to injection of melanocytes into growing feathers of completely depigmented Smyth chickens. Lastly, we observed increased expression of CD40 and B7-1 in melanocytes derived from growing feathers of Smyth chickens treated with H2O2. Collectively, these results further support the notion of cell-mediated immune destruction of melanocytes in growing feathers. Furthermore, these data open new avenues of study in the vitiligo-prone Smyth line and vitiligo-susceptible Brown line chickens.
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