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Fibroblast Growth Factor 13 Regulate...

Sinden, Daniel Stephen.

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Fibroblast Growth Factor 13 Regulates Thermogenesis and Metabolism.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Fibroblast Growth Factor 13 Regulates Thermogenesis and Metabolism./
Author:	Sinden, Daniel Stephen.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	120 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
Contained By:	Dissertations Abstracts International80-12B.
Subject:	Cellular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10821636
ISBN:	9781392195123

Fibroblast Growth Factor 13 Regulates Thermogenesis and Metabolism.
Sinden, Daniel Stephen.

Fibroblast Growth Factor 13 Regulates Thermogenesis and Metabolism. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 120 p.

Source: Dissertations Abstracts International, Volume: 80-12, Section: B.

Thesis (Ph.D.)--Duke University, 2019.

This item must not be sold to any third party vendors.

The non-secreted fibroblast growth factor (FGF) homologous factor (FHF) FGF13 is a noncanonical FGF with identified roles in neuronal development, pain sensation, and cardiac physiology, but recent reports suggest broader roles. The in vivo functions of FGF13 have not been widely studied. In this study, we have generated a global heterozygous Fgf13 knockout mouse model. In these animals, we observed hyperactivity and accompanying reduced core body temperature in mice housed at 22 °C. In mice housed at 30 °C (thermoneutrality) we observed development of a pronounced obesity. Defects in thermogenesis and metabolism were found to be due to impaired central nervous system regulation of sympathetic activation of brown fat. Neuronal and hypothalamic specific ablation of Fgf13 recapitulated weight gain at 30 °C. In global heterozygous animals, norepinephrine turnover in brown fat was reduced at both housing temperatures, while direct activation of brown fat by a β3 agonist showed an intact response. Further, we found that FGF13 is a direct regulator of NaV1.7, a hypothalamic Na+ channel associated with regulation of body weight. Our data expand the physiologic roles for FGF13, and enhance the understanding of the multifunctional FHFs.

ISBN: 9781392195123Subjects--Topical Terms:

3172791
Cellular biology.

Fibroblast Growth Factor 13 Regulates Thermogenesis and Metabolism.
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500 $a Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
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502 $a Thesis (Ph.D.)--Duke University, 2019.
506 $a This item must not be sold to any third party vendors.
520 $a The non-secreted fibroblast growth factor (FGF) homologous factor (FHF) FGF13 is a noncanonical FGF with identified roles in neuronal development, pain sensation, and cardiac physiology, but recent reports suggest broader roles. The in vivo functions of FGF13 have not been widely studied. In this study, we have generated a global heterozygous Fgf13 knockout mouse model. In these animals, we observed hyperactivity and accompanying reduced core body temperature in mice housed at 22 °C. In mice housed at 30 °C (thermoneutrality) we observed development of a pronounced obesity. Defects in thermogenesis and metabolism were found to be due to impaired central nervous system regulation of sympathetic activation of brown fat. Neuronal and hypothalamic specific ablation of Fgf13 recapitulated weight gain at 30 °C. In global heterozygous animals, norepinephrine turnover in brown fat was reduced at both housing temperatures, while direct activation of brown fat by a β3 agonist showed an intact response. Further, we found that FGF13 is a direct regulator of NaV1.7, a hypothalamic Na+ channel associated with regulation of body weight. Our data expand the physiologic roles for FGF13, and enhance the understanding of the multifunctional FHFs.
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