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Overcoming Clinical Challenges to Ti...

Cohen, Benjamin Peter.

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Overcoming Clinical Challenges to Tissue Engineering the Human Auricle.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Overcoming Clinical Challenges to Tissue Engineering the Human Auricle./
Author:	Cohen, Benjamin Peter.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	284 p.
Notes:	Source: Dissertation Abstracts International, Volume: 80-05(E), Section: B.
Contained By:	Dissertation Abstracts International80-05B(E).
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10980265
ISBN:	9780438782846

Overcoming Clinical Challenges to Tissue Engineering the Human Auricle.
Cohen, Benjamin Peter.

Overcoming Clinical Challenges to Tissue Engineering the Human Auricle. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 284 p.

Source: Dissertation Abstracts International, Volume: 80-05(E), Section: B.

Thesis (Ph.D.)--Cornell University, 2018.

Autologous costal cartilage and alloplastic implant reconstruction for deformed or damaged auricles fail to accurately replicate the complex morphology of the ear or the structure, composition, or mechanics of auricular cartilage. Tissue engineering can provide patient-specific auricular replacements featuring robust auricular cartilage, but several challenges to clinical translation must first be addressed (Chapter 1). Advances in bioimaging and additive manufacturing technology have allowed for improved morphology following construct generation and have the potential to further the clinical transition by making tissue-engineered auricles more accessible, reproducible, and scalable (Chapter 2).

ISBN: 9780438782846Subjects--Topical Terms:

535387
Biomedical engineering.

Overcoming Clinical Challenges to Tissue Engineering the Human Auricle.
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100 1 $a Cohen, Benjamin Peter. $0 (orcid)0000-0001-5165-6788 $3 3431230
245 1 0 $a Overcoming Clinical Challenges to Tissue Engineering the Human Auricle.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 284 p.
500 $a Source: Dissertation Abstracts International, Volume: 80-05(E), Section: B.
500 $a Includes supplementary digital materials.
500 $a Adviser: Lawrence J. Bonassar.
502 $a Thesis (Ph.D.)--Cornell University, 2018.
520 $a Autologous costal cartilage and alloplastic implant reconstruction for deformed or damaged auricles fail to accurately replicate the complex morphology of the ear or the structure, composition, or mechanics of auricular cartilage. Tissue engineering can provide patient-specific auricular replacements featuring robust auricular cartilage, but several challenges to clinical translation must first be addressed (Chapter 1). Advances in bioimaging and additive manufacturing technology have allowed for improved morphology following construct generation and have the potential to further the clinical transition by making tissue-engineered auricles more accessible, reproducible, and scalable (Chapter 2).
520 $a The stability of an engineered ear following implantation is of critical importance to the clinical outcome. Long-term implantation of full-size pediatric auricles was performed to ascertain the development of a tissue-engineered ear (Chapter 3). Auricular chondrocytes (AuCs) have limited clinical accessibility, whereas mesenchymal stem cells (MSCs) can be acquired in large numbers with relatively minimal surgery. The capacity for MSCs to reduce AuC requirement for auricular cartilage tissue engineering was evaluated (Chapter 4 and Appendix A). The limits of AuC expansion without impairment of cartilage generating properties was also explored (Chapter 5). Finally, cell-seeded collagen hydrogel constructs consistently demonstrate contraction following implantation, negatively impacting construct morphology and amount of tissue generated. Low oxygen tensions similar to the state of native cartilage tissue were applied to AuCs during both expansion and three-dimensional culture to determine the effect on construct shape maintenance and cartilage development (Chapter 6).
520 $a Collectively, this dissertation demonstrates the stability of patient-specific, tissue-engineered ears during in vivo growth, while also providing multiple avenues for clinical cell sourcing and a method for preventing changes in construct morphology (Chapter 7). This work shows the potential for tissue engineering as a superior option for auricular reconstruction and overcomes several of the obstacles towards clinical translation of this technique.
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773 0 $t Dissertation Abstracts International $g 80-05B(E).
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