東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Investigation of Small Molecule Medi...

Jones, Corey L.

Linked to FindBook

Google Book

Amazon

博客來

Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity./
Author:	Jones, Corey L.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	226 p.
Notes:	Source: Dissertation Abstracts International, Volume: 80-09(E), Section: B.
Contained By:	Dissertation Abstracts International80-09B(E).
Subject:	Organic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13860910
ISBN:	9781392146941

Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity.
Jones, Corey L.

Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 226 p.

Source: Dissertation Abstracts International, Volume: 80-09(E), Section: B.

Thesis (Ph.D.)--Michigan State University, 2019.

Proteins undergo constant proteolytic degradation to regulate intracellular processes and maintain biological homeostasis. One of the main intracellular proteolytic pathways involves the proteasome, which is responsible for the degradation of misfolded, oxidatively damaged, and redundant proteins. The age-related decline of the efficiency of this enzymatic pathway leads to accumulation of aberrant proteins which leads to aggregates and a host of amyloidosis disease states. Small molecule intervention has been suggested as a viable therapeutic strategy; however, enhancement of proteasome activity is not well understood. This work details efforts and evidence for mechanistic understanding of how small molecule action may enhance and bias proteasome proteolysis and provides a theoretical model for further advancement.

ISBN: 9781392146941Subjects--Topical Terms:

523952
Organic chemistry.

Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity.
LDR:01874nmm a2200301 4500 001 2204089
005 20190624102129.5
008 201008s2019 ||||||||||||||||| ||eng d
020 $a 9781392146941
035 $a (MiAaPQ)AAI13860910
035 $a (MiAaPQ)grad.msu:16688
035 $a AAI13860910
040 $a MiAaPQ $c MiAaPQ
100 1 $a Jones, Corey L. $3 3430908
245 1 0 $a Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 226 p.
500 $a Source: Dissertation Abstracts International, Volume: 80-09(E), Section: B.
500 $a Adviser: Jetze J. Tepe.
502 $a Thesis (Ph.D.)--Michigan State University, 2019.
520 $a Proteins undergo constant proteolytic degradation to regulate intracellular processes and maintain biological homeostasis. One of the main intracellular proteolytic pathways involves the proteasome, which is responsible for the degradation of misfolded, oxidatively damaged, and redundant proteins. The age-related decline of the efficiency of this enzymatic pathway leads to accumulation of aberrant proteins which leads to aggregates and a host of amyloidosis disease states. Small molecule intervention has been suggested as a viable therapeutic strategy; however, enhancement of proteasome activity is not well understood. This work details efforts and evidence for mechanistic understanding of how small molecule action may enhance and bias proteasome proteolysis and provides a theoretical model for further advancement.
590 $a School code: 0128.
650 4 $a Organic chemistry. $3 523952
650 4 $a Chemistry. $3 516420
690 $a 0490
690 $a 0485
710 2 $a Michigan State University. $b Chemistry - Doctor of Philosophy. $3 2094041
773 0 $t Dissertation Abstracts International $g 80-09B(E).
790 $a 0128
791 $a Ph.D.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13860910