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Reduction of Ketones to Alcohols and...

Varjosaari, Sami Ensio.

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Reduction of Ketones to Alcohols and Tertiary Amines Using 1-Hydrosilatrane.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Reduction of Ketones to Alcohols and Tertiary Amines Using 1-Hydrosilatrane./
Author:	Varjosaari, Sami Ensio.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	437 p.
Notes:	Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Contained By:	Dissertation Abstracts International79-10B(E).
Subject:	Organic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10785985
ISBN:	9780438032569

Reduction of Ketones to Alcohols and Tertiary Amines Using 1-Hydrosilatrane.
Varjosaari, Sami Ensio.

Reduction of Ketones to Alcohols and Tertiary Amines Using 1-Hydrosilatrane. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 437 p.

Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.

Thesis (Ph.D.)--Northern Illinois University, 2018.

1-Hydrosilatrane is an easily synthesized, stable, solid silane which can be made into an efficient reducing agent in the presence of a Lewis base, by taking advantage of the properties of hypervalent silicon. Due to the simplicity of use and handling, 1-hydrosilatrane has the potential to be an appealing alternative to other more widely used reducing agents. Aromatic and aliphatic ketones were readily reduced with 1-hydrosilatrane in the presence of potassium tert-butoxide. The discovery of diastereoselectivity in the reduction of menthone, a chiral ketone, led to enantioselective reductions of prochiral ketones using chiral Lewis base activators. Enantiomeric excesses of up to 86% were observed. It was also shown that 1-hydrosilatrane could act as a chemoselective reducing agent in the formation of tertiary amines via direct reductive aminations, in the absence of activator or solvent. Attempts were also made to take advantage of the steric properties of silicon protecting groups in meta-directing electrophilic aromatic substitution of phenols, leading to a one-pot synthesis of O-aryl carbamates.

ISBN: 9780438032569Subjects--Topical Terms:

523952
Organic chemistry.

Reduction of Ketones to Alcohols and Tertiary Amines Using 1-Hydrosilatrane.
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520 $a 1-Hydrosilatrane is an easily synthesized, stable, solid silane which can be made into an efficient reducing agent in the presence of a Lewis base, by taking advantage of the properties of hypervalent silicon. Due to the simplicity of use and handling, 1-hydrosilatrane has the potential to be an appealing alternative to other more widely used reducing agents. Aromatic and aliphatic ketones were readily reduced with 1-hydrosilatrane in the presence of potassium tert-butoxide. The discovery of diastereoselectivity in the reduction of menthone, a chiral ketone, led to enantioselective reductions of prochiral ketones using chiral Lewis base activators. Enantiomeric excesses of up to 86% were observed. It was also shown that 1-hydrosilatrane could act as a chemoselective reducing agent in the formation of tertiary amines via direct reductive aminations, in the absence of activator or solvent. Attempts were also made to take advantage of the steric properties of silicon protecting groups in meta-directing electrophilic aromatic substitution of phenols, leading to a one-pot synthesis of O-aryl carbamates.
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