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Structural and biochemical character...

Brauning, Bastian.

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Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica

Record Type:	Electronic resources : Monograph/item
Title/Author:	Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica/ by Bastian Brauning.
Author:	Brauning, Bastian.
Published:	Cham :Springer International Publishing : : 2019.,
Description:	xxxi, 86 p. :ill., digital ;24 cm.
[NT 15003449]:	Introduction -- Objectives -- Materials & Methods -- Results -- Discussion.
Contained By:	Springer eBooks
Subject:	Toxins. -
Online resource:	https://doi.org/10.1007/978-3-030-29439-7
ISBN:	9783030294397

Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica
Brauning, Bastian.

Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica[electronic resource] /by Bastian Brauning. - Cham :Springer International Publishing :2019. - xxxi, 86 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Objectives -- Materials & Methods -- Results -- Discussion.

This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families. Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Brauning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts.

ISBN: 9783030294397

Standard No.: 10.1007/978-3-030-29439-7doiSubjects--Topical Terms:

789124
Toxins.

LC Class. No.: QP631 / .B786 2019

Dewey Class. No.: 615.95

Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica
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100 1 $a Brauning, Bastian. $3 3413979
245 1 0 $a Structural and biochemical characterization of the YaxAB pore-forming toxin from Yersinia enterocolitica $h [electronic resource] / $c by Bastian Brauning.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2019.
300 $a xxxi, 86 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Introduction -- Objectives -- Materials & Methods -- Results -- Discussion.
520 $a This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families. Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Brauning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts.
650 0 $a Toxins. $3 789124
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650 2 4 $a Biochemical Engineering. $3 892423
650 2 4 $a Bacteriology. $3 641499
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950 $a Chemistry and Materials Science (Springer-11644)