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Blood flow patterns, arterial Reynol...

Gurovich, Alvaro N.

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Blood flow patterns, arterial Reynolds number, exercise, and endothelial function.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Blood flow patterns, arterial Reynolds number, exercise, and endothelial function./
作者:	Gurovich, Alvaro N.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2010,
面頁冊數:	138 p.
附註:	Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: 2613.
Contained By:	Dissertation Abstracts International72-05B.
標題:	Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3447043
ISBN:	9781124514109

Blood flow patterns, arterial Reynolds number, exercise, and endothelial function.
Gurovich, Alvaro N.

Blood flow patterns, arterial Reynolds number, exercise, and endothelial function. - Ann Arbor : ProQuest Dissertations & Theses, 2010 - 138 p.

Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: 2613.

Thesis (Ph.D.)--University of Florida, 2010.

This item is not available from ProQuest Dissertations & Theses.

Endothelial dysfunction is the first pathophysiological step in atherosclerosis. It has been shown that exercise training improves endothelial function via direct effects on cardiovascular risk factors. However, direct effects of exercise-induced blood flow on endothelial function are controversial. We hypothesized that exercise training-induced endothelial function improvement is (1) systemic and not only localized in exercising vascular beds, and (2) that improved endothelial function is mediated by retrograde turbulent and antegrade laminar blood flow patterns. To test our central hypotheses, we designed three in-vivo experiments (1) to characterize beneficial blood flow patterns, (2) to characterize blood flow patterns during different exercise types and intensities, and (3) to determine possible mechanisms involved on endothelial function regulation produced by exercise-induced blood flow as a mechanical stimulus.

ISBN: 9781124514109Subjects--Topical Terms:

518431
Physiology.

Blood flow patterns, arterial Reynolds number, exercise, and endothelial function.
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245 1 0 $a Blood flow patterns, arterial Reynolds number, exercise, and endothelial function.
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300 $a 138 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: 2613.
500 $a Includes supplementary digital materials.
500 $a Adviser: Randy W. Braith.
502 $a Thesis (Ph.D.)--University of Florida, 2010.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Endothelial dysfunction is the first pathophysiological step in atherosclerosis. It has been shown that exercise training improves endothelial function via direct effects on cardiovascular risk factors. However, direct effects of exercise-induced blood flow on endothelial function are controversial. We hypothesized that exercise training-induced endothelial function improvement is (1) systemic and not only localized in exercising vascular beds, and (2) that improved endothelial function is mediated by retrograde turbulent and antegrade laminar blood flow patterns. To test our central hypotheses, we designed three in-vivo experiments (1) to characterize beneficial blood flow patterns, (2) to characterize blood flow patterns during different exercise types and intensities, and (3) to determine possible mechanisms involved on endothelial function regulation produced by exercise-induced blood flow as a mechanical stimulus.
520 $a We recruited 53 apparently healthy, young men for the three studies (18 on the first, 8 on the second, and 27 for the third one) and the most relevant results showed (1) beneficial blood flows include two opposite patterns: antegrade laminar and retrograde turbulent; (2) retrograde turbulent blood flow is increased during cycling exercise in a dose-dependent manner; and (3) exercise-induced blood flow regulates endothelial function via a decrease on endothelial oxidative stress and increase on endothelial nitric oxide synthase.
520 $a These results provide, for the first time, evidence in support of the hypothesis that exercise-induced blood flow regulation of endothelial function is dependent upon blood flow pattern. In addition, these results provide further evidence of the close relationship between endothelial function, endothelial nitric oxide synthase, and endothelial cell oxidative stress in vivo. .
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