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Patent Ductus Arteriosus Ligation in...

Weisz, Dany.

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Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment./
Author:	Weisz, Dany.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	132 p.
Notes:	Source: Masters Abstracts International, Volume: 56-03.
Contained By:	Masters Abstracts International56-03(E).
Subject:	Medicine. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10194545
ISBN:	9781369666489

Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
Weisz, Dany.

Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 132 p.

Source: Masters Abstracts International, Volume: 56-03.

Thesis (M.Sc.)--University of Toronto (Canada), 2016.

This item is not available from ProQuest Dissertations & Theses.

Objective: Evaluate the association between patent ductus arteriosus (PDA) ligation vs. medical management and neonatal and neurodevelopmental outcomes.

ISBN: 9781369666489Subjects--Topical Terms:

641104
Medicine.

Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
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020 $a 9781369666489
035 $a (MiAaPQ)AAI10194545
035 $a (MiAaPQ)toronto:14678
035 $a AAI10194545
040 $a MiAaPQ $c MiAaPQ
100 1 $a Weisz, Dany. $3 3349242
245 1 0 $a Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 132 p.
500 $a Source: Masters Abstracts International, Volume: 56-03.
500 $a Adviser: Prakesh S. Shah.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2016.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Objective: Evaluate the association between patent ductus arteriosus (PDA) ligation vs. medical management and neonatal and neurodevelopmental outcomes.
520 $a Methods: Retrospective cohort study of extremely preterm infants with PDA born between 2006-2012. The primary outcome was death or neurodevelopmental impairment (NDI) at 18-24 months. Secondary outcomes included death, chronic lung disease (CLD), and NDI. Multivariable logistic regression (MLR) analysis and marginal structural models (MSM) were used to adjust for perinatal and postnatal confounders.
520 $a Results: Of 754 infants with PDA, 184(24%) underwent ligation. Compared with medically treated infants, ligated infants had similar odds of death/NDI (aOR 0.83, 95%CI:0.52-1.32), NDI (aOR 1.27, 95%CI:0.78--2.06), and CLD (aOR 1.36, 95%CI:0.78--2.39), but lower mortality (aOR 0.09, 95%CI:0.04--0.21).
520 $a Conclusions: PDA ligation is not associated with adverse outcomes and may reduce mortality. Previously reported associations of ligation with increased morbidity are likely due to bias from confounding by indication, rather than a detrimental causal effect of ligation.
590 $a School code: 0779.
650 4 $a Medicine. $3 641104
650 4 $a Epidemiology. $3 568544
650 4 $a Biostatistics. $3 1002712
690 $a 0564
690 $a 0766
690 $a 0308
710 2 $a University of Toronto (Canada). $b Health Policy, Management and Evaluation. $3 2105918
773 0 $t Masters Abstracts International $g 56-03(E).
790 $a 0779
791 $a M.Sc.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10194545