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Optogenetic-fMRI Investigations of A...

Liu, Jia.

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Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies./
Author:	Liu, Jia.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	145 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-06(E), Section: B.
Contained By:	Dissertation Abstracts International78-06B(E).
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10246039
ISBN:	9781369430219

Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies.
Liu, Jia.

Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 145 p.

Source: Dissertation Abstracts International, Volume: 78-06(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2016.

This item is not available from ProQuest Dissertations & Theses.

Optogenetic functional magnetic resonance imaging (ofMRI) is a novel technique that enables whole-brain visualization of the downstream effects of manipulating a specific neural population. This thesis presents two studies that demonstrate the advantages of ofMRI in brain circuit analysis and offer practical recommendations for ofMRI data analysis. We first describe a study where the technical advantage of ofMRI is utilized in the investigation of arousal networks. The role of central thalamus in forebrain arousal and the frequency-selective modulation of whole-brain networks are uncovered. We then address the challenges of accurate detection and characterization of hemodynamic responses with highly variable temporal dynamics in the ofMRI datasets. In order to find the optimal analysis method, a comprehensive evaluation of the commonly used approaches is presented.

ISBN: 9781369430219Subjects--Topical Terms:

588700
Neurosciences.

Optogenetic-fMRI Investigations of Arousal Networks and Analysis Strategies.
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500 $a Source: Dissertation Abstracts International, Volume: 78-06(E), Section: B.
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520 $a Optogenetic functional magnetic resonance imaging (ofMRI) is a novel technique that enables whole-brain visualization of the downstream effects of manipulating a specific neural population. This thesis presents two studies that demonstrate the advantages of ofMRI in brain circuit analysis and offer practical recommendations for ofMRI data analysis. We first describe a study where the technical advantage of ofMRI is utilized in the investigation of arousal networks. The role of central thalamus in forebrain arousal and the frequency-selective modulation of whole-brain networks are uncovered. We then address the challenges of accurate detection and characterization of hemodynamic responses with highly variable temporal dynamics in the ofMRI datasets. In order to find the optimal analysis method, a comprehensive evaluation of the commonly used approaches is presented.
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