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Design and Evaluation of Novel Topic...

Sivaraman, Arunprasad.

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Design and Evaluation of Novel Topical, Transdermal and Microneedle Formulations.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Design and Evaluation of Novel Topical, Transdermal and Microneedle Formulations./
Author:	Sivaraman, Arunprasad.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	178 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
Subject:	Pharmaceutical sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10264692
ISBN:	9781369721119

Design and Evaluation of Novel Topical, Transdermal and Microneedle Formulations.
Sivaraman, Arunprasad.

Design and Evaluation of Novel Topical, Transdermal and Microneedle Formulations. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 178 p.

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (D.Phil.)--Mercer University, 2017.

Purpose: The broad aim of this project was to formulate passive transdermal patches, topical gel and microneedle and evaluate their physical properties and delivery efficiency via skin.

ISBN: 9781369721119Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Design and Evaluation of Novel Topical, Transdermal and Microneedle Formulations.
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100 1 $a Sivaraman, Arunprasad. $3 3345257
245 1 0 $a Design and Evaluation of Novel Topical, Transdermal and Microneedle Formulations.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 178 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
500 $a Adviser: Ajay K. Banga.
502 $a Thesis (D.Phil.)--Mercer University, 2017.
520 $a Purpose: The broad aim of this project was to formulate passive transdermal patches, topical gel and microneedle and evaluate their physical properties and delivery efficiency via skin.
520 $a Methods: Polyvinyl alcohol polymer transdermal patch was prepared in combination with DURO-TAK(TM) 387-2516 acrylate adhesive using oxybutynin and characterized for coating efficiency, matrix structure, rheology, tack, shear, peel adhesion and tested for in vitro permeation using dermatomed human skin for 72 hours.
520 $a A semi-synthetic opioid transdermal patch was prepared using a formulation blend of oleic acid, BIO-PSA 7 - 4301 silicone adhesive and an amphiphilic solvent and characterized for coating efficiency, matrix structure, thickness, tack, peel adhesion and tested for in vitro permeation using dermatomed human skin for 72 hours.
520 $a In situ forming hydrogel microneedles were investigated using a non-ionic triblock thermosensitive copolymer with methotrexate. The microneedles were characterized for sol-gel transition, geometry, depth of micropores, histology, rheology, methylene blue staining and evaluated for transdermal delivery in full thickness porcine ear skin and dermatomed human skin.
520 $a A topical diclofenac gel was prepared using polyvinyl alcohol polymer and characterized for matrix arrangement, pH, adhesion, spreading efficiency, crystallization, rheology, skin irritation and evaluated for in vitro drug distribution and permeation with dermatomed human skin.
520 $a Results and Conclusions: The polyvinyl alcohol transdermal patch showed an emulsion matrix formation with an average in vitro cumulative permeation and flux of 343.80 +/- 74.36 mug/cm2 and 4.79 +/- 1.3 mug/cm2/h respectively with no skin irritation. The semi-synthetic opioid transdermal patch delivered an average drug cumulative permeation and flux of 25.98 +/- 0.19 mug/cm 2 and 0.28 +/- 0.2 mug/cm2/h respectively with no drug crystallization. The in situ formed hydrogel microneedles delivered an average cumulative drug amount of 32.2 +/- 15.76 mug/sq.cm and 114.54 +/- 40.89 mug/sq.cm for porcine ear skin from 0.2% w/w and 0.4% w/w methotrexate formulations. The topical diclofenac gel delivered an average cumulative drug amount of 22.85 +/- 9.41 mug/cm2 and distribution of 10.30 +/- 9.09 mug/cm2 for 24 h with no skin irritation. In conclusion, transdermal patches, topical gel and microneedles were formulated and characterized for their physical properties and evaluated for skin delivery.
590 $a School code: 1160.
650 4 $a Pharmaceutical sciences. $3 3173021
690 $a 0572
710 2 $a Mercer University. $b Pharmacy. $3 3345258
773 0 $t Dissertation Abstracts International $g 78-09B(E).
790 $a 1160
791 $a D.Phil.
792 $a 2017
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10264692