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A Study on Reversing the Immunosuppr...

Liddle, Genevieve Margaret.

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A Study on Reversing the Immunosuppressive Phenotype of Tumor Associated Macrophages.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A Study on Reversing the Immunosuppressive Phenotype of Tumor Associated Macrophages./
Author:	Liddle, Genevieve Margaret.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	42 p.
Notes:	Source: Masters Abstracts International, Volume: 56-04.
Contained By:	Masters Abstracts International56-04(E).
Subject:	Biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10610531
ISBN:	9781369849639

A Study on Reversing the Immunosuppressive Phenotype of Tumor Associated Macrophages.
Liddle, Genevieve Margaret.

A Study on Reversing the Immunosuppressive Phenotype of Tumor Associated Macrophages. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 42 p.

Source: Masters Abstracts International, Volume: 56-04.

Thesis (M.S.)--Florida Atlantic University, 2017.

Extracellular stimuli may influence the M1/M2 phenotypic polarization of macrophages. We examined M1/M2 biomarkers, phagocytic activity, and tumoricidal activity in RAW 264.7 mouse macrophages. Macrophages were treated with conditioned media (CM) from 4T1 breast cancer cells, curcumin, 22-oxacalcitriol, LPS, or a combination of the previously listed. Arginase activity, a M2 phenotypic biomarker, was upregulated by the treatment of macrophages with conditioned media. Curcumin, 22- oxacalcitriol, and LPS partially inhibited RAW 264.7 arginase activity in the presence of 4T1 breast cancer media. 22-oxacalcitriol increased the phagocytic ability of RAW 264.7 macrophages in the presence of M2 polarizing substances produced by the 4T1 breast cancer cells. Also, LPS increased RAW 264.7 phagocytic ability in the presence of 4T1 breast cancer CM. This study looked at the potential substances that would possibly reverse the M2 tumor promoting macrophage phenotype seen in the breast cancer tumor environment.

ISBN: 9781369849639Subjects--Topical Terms:

522710
Biology.

A Study on Reversing the Immunosuppressive Phenotype of Tumor Associated Macrophages.
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500 $a Source: Masters Abstracts International, Volume: 56-04.
500 $a Adviser: James X. Hartmann.
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520 $a Extracellular stimuli may influence the M1/M2 phenotypic polarization of macrophages. We examined M1/M2 biomarkers, phagocytic activity, and tumoricidal activity in RAW 264.7 mouse macrophages. Macrophages were treated with conditioned media (CM) from 4T1 breast cancer cells, curcumin, 22-oxacalcitriol, LPS, or a combination of the previously listed. Arginase activity, a M2 phenotypic biomarker, was upregulated by the treatment of macrophages with conditioned media. Curcumin, 22- oxacalcitriol, and LPS partially inhibited RAW 264.7 arginase activity in the presence of 4T1 breast cancer media. 22-oxacalcitriol increased the phagocytic ability of RAW 264.7 macrophages in the presence of M2 polarizing substances produced by the 4T1 breast cancer cells. Also, LPS increased RAW 264.7 phagocytic ability in the presence of 4T1 breast cancer CM. This study looked at the potential substances that would possibly reverse the M2 tumor promoting macrophage phenotype seen in the breast cancer tumor environment.
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