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Neurobiological Mechanisms by which ...

Sivaselvachandran, Sivaani.

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Neurobiological Mechanisms by which Stress Prevents Empathy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Neurobiological Mechanisms by which Stress Prevents Empathy./
Author:	Sivaselvachandran, Sivaani.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	63 p.
Notes:	Source: Masters Abstracts International, Volume: 56-03.
Contained By:	Masters Abstracts International56-03(E).
Subject:	Psychobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10194959
ISBN:	9781369660074

Neurobiological Mechanisms by which Stress Prevents Empathy.
Sivaselvachandran, Sivaani.

Neurobiological Mechanisms by which Stress Prevents Empathy. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 63 p.

Source: Masters Abstracts International, Volume: 56-03.

Thesis (M.A.)--University of Toronto (Canada), 2016.

Mice have the capacity to transmit pain status amongst familiars, which is understood to represent empathy in rodents. Recent findings show that the stress of a social interaction with an unfamiliar mouse can block empathy, while inhibiting the endocrine stress response of unfamiliar mice can evoke it. Experiments were conducted on naive male CD-1 RTM mice and found higher pain responses when familiars were tested together as opposed to with strangers. Western blot analysis demonstrated higher glucocorticoid activity in empathy involved regions (prefrontal cortex and anterior cingulate cortex) of mice in the unfamiliar condition compared to the familiar condition. The administration of Metyrapone (to block stress response) before testing resulted in higher pain responses in unfamiliars compared to isolated mice however no significant difference was found between Metyrapone pretreated unfamiliars and saline pretreated unfamiliars. These findings begin to uncover the neurobiological mechanisms by which stress prevents empathy using rodent models.

ISBN: 9781369660074Subjects--Topical Terms:

555678
Psychobiology.

Neurobiological Mechanisms by which Stress Prevents Empathy.
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245 1 0 $a Neurobiological Mechanisms by which Stress Prevents Empathy.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 63 p.
500 $a Source: Masters Abstracts International, Volume: 56-03.
500 $a Includes supplementary digital materials.
500 $a Adviser: Loren J. Martin.
502 $a Thesis (M.A.)--University of Toronto (Canada), 2016.
520 $a Mice have the capacity to transmit pain status amongst familiars, which is understood to represent empathy in rodents. Recent findings show that the stress of a social interaction with an unfamiliar mouse can block empathy, while inhibiting the endocrine stress response of unfamiliar mice can evoke it. Experiments were conducted on naive male CD-1 RTM mice and found higher pain responses when familiars were tested together as opposed to with strangers. Western blot analysis demonstrated higher glucocorticoid activity in empathy involved regions (prefrontal cortex and anterior cingulate cortex) of mice in the unfamiliar condition compared to the familiar condition. The administration of Metyrapone (to block stress response) before testing resulted in higher pain responses in unfamiliars compared to isolated mice however no significant difference was found between Metyrapone pretreated unfamiliars and saline pretreated unfamiliars. These findings begin to uncover the neurobiological mechanisms by which stress prevents empathy using rodent models.
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