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Nuclear pore complexes in genome org...

D'Angelo, Maximiliano.

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Nuclear pore complexes in genome organization, function and maintenance

Record Type:	Electronic resources : Monograph/item
Title/Author:	Nuclear pore complexes in genome organization, function and maintenance/ edited by Maximiliano D'Angelo.
other author:	D'Angelo, Maximiliano.
Published:	Cham :Springer International Publishing : : 2018.,
Description:	viii, 240 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Eukaryotic cells - Genetics. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-71614-5
ISBN:	9783319716145

Nuclear pore complexes in genome organization, function and maintenance
Nuclear pore complexes in genome organization, function and maintenance[electronic resource] /edited by Maximiliano D'Angelo. - Cham :Springer International Publishing :2018. - viii, 240 p. :ill., digital ;24 cm.

The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.

ISBN: 9783319716145

Standard No.: 10.1007/978-3-319-71614-5doiSubjects--Topical Terms:

3301495
Eukaryotic cells
--Genetics.

LC Class. No.: QH430

Dewey Class. No.: 571.66

Nuclear pore complexes in genome organization, function and maintenance
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245 0 0 $a Nuclear pore complexes in genome organization, function and maintenance $h [electronic resource] / $c edited by Maximiliano D'Angelo.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2018.
300 $a viii, 240 p. : $b ill., digital ; $c 24 cm.
520 $a The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.
650 0 $a Eukaryotic cells $x Genetics. $3 3301495
650 0 $a Cell nuclei. $3 595463
650 1 4 $a Biomedicine. $3 890831
650 2 4 $a Gene Function. $3 1067308
650 2 4 $a Gene Expression. $3 600530
650 2 4 $a Cell Biology. $3 892383
700 1 $a D'Angelo, Maximiliano. $3 3301494
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-71614-5
950 $a Biomedical and Life Sciences (Springer-11642)