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Connected Language in Early Mild Cog...

Mueller, Kimberly Diggle.

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Connected Language in Early Mild Cognitive Impairment.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Connected Language in Early Mild Cognitive Impairment./
Author:	Mueller, Kimberly Diggle.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	224 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
Contained By:	Dissertation Abstracts International78-10B(E).
Subject:	Speech therapy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10286620
ISBN:	9781369825923

Connected Language in Early Mild Cognitive Impairment.
Mueller, Kimberly Diggle.

Connected Language in Early Mild Cognitive Impairment. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 224 p.

Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2017.

Research evidence continues to accrue suggesting that pathological changes associated with Alzheimer's disease (AD) occur years or decades before the onset of cognitive and functional symptoms. As a result, there is an urgent need for sensitive measures that can detect the earliest functional and cognitive change. Connected language analysis, in which spoken language is assessed within the context of discourse, is a promising tool for early diagnosis of functional changes, because it more closely approximates everyday language use than traditional standardized language tests and thus may be more sensitive to early changes. Although many studies have documented changes in connected language in AD, little is known about when language difficulties first emerge on the path to a clinical diagnosis. The goal of this work was to investigate whether or not changes in connected language could be detected in a group of late-middle-aged, asymptomatic adults at risk for AD. We first compared the connected language of cognitively stable individuals to those identified as having early memory declines ("eMCI"), using a cross-sectional, matched-pairs design. Results showed that the eMCI group produced less informative language than the cognitively stable group. Next, we characterized the psychometric properties of connected language measures. We identified four factors of connected language in a group of cognitively stable adults: semantic, lexical, syntax, and fluency. These factors were invariant across sex and parental history of AD, and stable at two time points. Finally, we used the confirmed factor structure to evaluate connected language across two time points. We found that adults with eMCI declined more rapidly in semantic and fluency measures than adults who were cognitively stable. We also found that change in fluency and semantics, and lower baseline syntax predicted eMCI diagnosis at the second visit. This work provides evidence that changes in everyday language may be detected at very early preclinical stages of cognitive decline. Connected speech and language may be a useful performance-based tool for assessing and monitoring early functional declines.

ISBN: 9781369825923Subjects--Topical Terms:

520446
Speech therapy.

Connected Language in Early Mild Cognitive Impairment.
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245 1 0 $a Connected Language in Early Mild Cognitive Impairment.
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300 $a 224 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
500 $a Adviser: Lyn S. Turkstra.
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520 $a Research evidence continues to accrue suggesting that pathological changes associated with Alzheimer's disease (AD) occur years or decades before the onset of cognitive and functional symptoms. As a result, there is an urgent need for sensitive measures that can detect the earliest functional and cognitive change. Connected language analysis, in which spoken language is assessed within the context of discourse, is a promising tool for early diagnosis of functional changes, because it more closely approximates everyday language use than traditional standardized language tests and thus may be more sensitive to early changes. Although many studies have documented changes in connected language in AD, little is known about when language difficulties first emerge on the path to a clinical diagnosis. The goal of this work was to investigate whether or not changes in connected language could be detected in a group of late-middle-aged, asymptomatic adults at risk for AD. We first compared the connected language of cognitively stable individuals to those identified as having early memory declines ("eMCI"), using a cross-sectional, matched-pairs design. Results showed that the eMCI group produced less informative language than the cognitively stable group. Next, we characterized the psychometric properties of connected language measures. We identified four factors of connected language in a group of cognitively stable adults: semantic, lexical, syntax, and fluency. These factors were invariant across sex and parental history of AD, and stable at two time points. Finally, we used the confirmed factor structure to evaluate connected language across two time points. We found that adults with eMCI declined more rapidly in semantic and fluency measures than adults who were cognitively stable. We also found that change in fluency and semantics, and lower baseline syntax predicted eMCI diagnosis at the second visit. This work provides evidence that changes in everyday language may be detected at very early preclinical stages of cognitive decline. Connected speech and language may be a useful performance-based tool for assessing and monitoring early functional declines.
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