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Development and Translation of 3D Dy...

Chen, Hsin-Yu.

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Development and Translation of 3D Dynamic Hyperpolarized 13C-MR Metabolic and Perfusion Imaging - From Mice to Patients.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development and Translation of 3D Dynamic Hyperpolarized 13C-MR Metabolic and Perfusion Imaging - From Mice to Patients./
Author:	Chen, Hsin-Yu.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	196 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10263645
ISBN:	9781369737882

Development and Translation of 3D Dynamic Hyperpolarized 13C-MR Metabolic and Perfusion Imaging - From Mice to Patients.
Chen, Hsin-Yu.

Development and Translation of 3D Dynamic Hyperpolarized 13C-MR Metabolic and Perfusion Imaging - From Mice to Patients. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 196 p.

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (Ph.D.)--University of California, San Francisco, 2017.

Hyperpolarized carbon-13 (HP-13C) is emerging as a powerful new molecular imaging technique utilizing specialized instrumentation and dynamic nuclear polarization (DNP) to provide a signal enhancement of over 5 orders of magnitude. HP-13C MRI has made possible quantitative detection of metabolism and perfusion in vivo with 13C-labelled biomarkers, which are safe, non-radioactive and nontoxic. Prostate cancer is the second deadliest cancer in US men, and has become a healthcare problem worldwide. A major challenge in the clinical management of prostate cancer is to determine its aggressiveness.

ISBN: 9781369737882Subjects--Topical Terms:

535387
Biomedical engineering.

Development and Translation of 3D Dynamic Hyperpolarized 13C-MR Metabolic and Perfusion Imaging - From Mice to Patients.
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100 1 $a Chen, Hsin-Yu. $3 3287246
245 1 0 $a Development and Translation of 3D Dynamic Hyperpolarized 13C-MR Metabolic and Perfusion Imaging - From Mice to Patients.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 196 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
500 $a Adviser: Daniel B. Vigneron.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2017.
520 $a Hyperpolarized carbon-13 (HP-13C) is emerging as a powerful new molecular imaging technique utilizing specialized instrumentation and dynamic nuclear polarization (DNP) to provide a signal enhancement of over 5 orders of magnitude. HP-13C MRI has made possible quantitative detection of metabolism and perfusion in vivo with 13C-labelled biomarkers, which are safe, non-radioactive and nontoxic. Prostate cancer is the second deadliest cancer in US men, and has become a healthcare problem worldwide. A major challenge in the clinical management of prostate cancer is to determine its aggressiveness.
520 $a Through this dissertation project, a 3D dynamic compressed sensing MRSI technique was advanced from preclinical imaging to phase II clinical trial prostate cancer research. I conducted simultaneous metabolic and perfusion imaging on a transgenic mouse model of prostate cancer (TRAMP) using co-polarized 13C pyruvate and urea. Pyruvate to lactate flux (kPL) was significantly higher (p<0.001, 0.056 +/- 0.005 versus 0.019 +/-0.001 sec-1) for high- versus low-grade TRAMP tumors, urea AUC significantly reduced (p<0.01, 640 +/- 94 versus 1407 +/- 221 AU), while k trans significantly increased (p<0.01, 358 +/- 38 versus 180 +/- 24 ml/dL/min). The HP-13C MRI outcomes strongly correlates with histological, gene expression and LDHA activity findings.
520 $a Translation from mice to humans requires overcoming challenges of larger imaging volume, reduce peak RF power, and decreased sensitivity. These challenges were addressed by designing new RF pulses that reduced 67% peak power, and transitioning from DSE to FID acquisitions without SNR loss. The improved sequence allows 0.5cm3 spatial and 2s temporal resolution, and enables reproducible human prostate acquisitions. "Goodness" of dynamic models was compared using Akaike's information criteria. Quantitative accuracy was improved using a B1-insensitive variable flip angle scheme. Also investigated was the impact of pulse sequence design and parameter on kPL estimation.
520 $a New sampling patterns are proposed for larger coverage or finer resolution, and an SVD-based algorithm was applied to allow parallel reconstruction of multichannel brain data. Finally, I investigated the response of androgen deprivation therapy from a prostate cancer patient, and found substantial decrease in kPL, which indicates the clinical potential of quantitative 3D dynamic HP-13C MRI for the detection of early treatment response.
590 $a School code: 0034.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
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710 2 $a University of California, San Francisco. $b Bioengineering. $3 1025199
773 0 $t Dissertation Abstracts International $g 78-09B(E).
790 $a 0034
791 $a Ph.D.
792 $a 2017
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10263645