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The Study of Complex Behavioral Chan...

Choi, Daniel Moon-hyung.

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The Study of Complex Behavioral Changes with Age in Drosophila melanogaster Using a Quantitative Framework for Behavioral Description.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Study of Complex Behavioral Changes with Age in Drosophila melanogaster Using a Quantitative Framework for Behavioral Description./
Author:	Choi, Daniel Moon-hyung.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	141 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-06(E), Section: B.
Contained By:	Dissertation Abstracts International78-06B(E).
Subject:	Behavioral sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10248434
ISBN:	9781369557282

The Study of Complex Behavioral Changes with Age in Drosophila melanogaster Using a Quantitative Framework for Behavioral Description.
Choi, Daniel Moon-hyung.

The Study of Complex Behavioral Changes with Age in Drosophila melanogaster Using a Quantitative Framework for Behavioral Description. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 141 p.

Source: Dissertation Abstracts International, Volume: 78-06(E), Section: B.

Thesis (Ph.D.)--Princeton University, 2017.

Aging is a set of complex, multi-factorial phenotypes that follow characteristic temporal profiles throughout an organism's life. Rather than looking at specific metabolic, hormonal, or genetic traits, researchers often focus on behaviors as a composite phenotype representative of an animal's physiological state. Behaviors, like aging, are also downstream of many biological processes, and are fundamentally dynamic traits. While some of the causal mechanisms of behavior have been studied at the genetic and physiological levels, we still have limited quantitative descriptions of behaviors. We present in this volume a framework for the study of animal behavior that establishes a mathematical language of ethological description. We demonstrate the feasibility of a quantitative phenomenology that can be used to wed the rigor of controlled behavioral experiments and the richness of observational data. Leveraging our ability to formally define a broad repertoire of behaviors, we examine age-related behavioral changes in the fruit fly Drosophila melanogaster, presenting novel findings in sexual dimorphism and models of neurodegenerative diseases. We use a data-driven approach to capture the quantitative profile of behavioral aging based on previous work developed to capture a broader behavioral repertoire. We find that individual behaviors exhibit qualitatively different aging profiles, and that these aging profiles differ depending on sex and across different neurodegenerative models. While we discover a number of findings that underscore the importance of specific pathways, the complexity of behavioral aging patterns uncovered by our work underscores the diversity of changes that occurs as an organism ages, highlighting the importance of examining multiple behavioral phenotypes in tandem in unraveling the programs and mechanisms of organismal aging. We believe that our work represents an important first step in obtaining a complete picture of how organisms behave throughout their lifespan, and it further serves as a compelling direction for the formalization of observational methods in ethology.

ISBN: 9781369557282Subjects--Topical Terms:

529833
Behavioral sciences.

The Study of Complex Behavioral Changes with Age in Drosophila melanogaster Using a Quantitative Framework for Behavioral Description.
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