東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Reverse transendothelial migration o...

Roufaiel, Mark.

FindBook

Google Book

Amazon

博客來

Reverse transendothelial migration of intimal CD11c + dendritic cells: Role in intracellular pathogen removal and effect on atherosclerotic lesions.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Reverse transendothelial migration of intimal CD11c + dendritic cells: Role in intracellular pathogen removal and effect on atherosclerotic lesions./
作者:	Roufaiel, Mark.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
面頁冊數:	208 p.
附註:	Source: Dissertation Abstracts International, Volume: 78-01(E), Section: B.
Contained By:	Dissertation Abstracts International78-01B(E).
標題:	Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10140572
ISBN:	9781339959696

Reverse transendothelial migration of intimal CD11c + dendritic cells: Role in intracellular pathogen removal and effect on atherosclerotic lesions.
Roufaiel, Mark.

Reverse transendothelial migration of intimal CD11c + dendritic cells: Role in intracellular pathogen removal and effect on atherosclerotic lesions. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 208 p.

Source: Dissertation Abstracts International, Volume: 78-01(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2016.

Dendritic cells are antigen presenting cells that play a key role in the initiation of the adaptive immune response and in chronic inflammatory diseases such as atherosclerosis. Resident intimal CD11c + cells are abundant in the normal arterial intima of mice, in regions predisposed to atherosclerosis. Upon induction of hypercholesterolemia, these cells engulf lipids and become the first foam cells in nascent lesions. However, their function in the normal aorta remains poorly understood. The purpose of this study is to show that their function is to protect the arterial intima against Chlamydia (C.) muridarum infection, and potentially against other intracellular and extracellular bacteria. This protection is achieved when intimal CD11c+ cells undergo reverse transendothelial migration (RTM) through the endothelium into the arterial circulation to remove the pathogen from the vessel wall.

ISBN: 9781339959696Subjects--Topical Terms:

611031
Immunology.

Reverse transendothelial migration of intimal CD11c + dendritic cells: Role in intracellular pathogen removal and effect on atherosclerotic lesions.
LDR:03623nmm a2200361 4500 001 2123959
005 20171023101701.5
008 180830s2016 ||||||||||||||||| ||eng d
020 $a 9781339959696
035 $a (MiAaPQ)AAI10140572
035 $a AAI10140572
040 $a MiAaPQ $c MiAaPQ
100 1 $a Roufaiel, Mark. $3 3285919
245 1 0 $a Reverse transendothelial migration of intimal CD11c + dendritic cells: Role in intracellular pathogen removal and effect on atherosclerotic lesions.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 208 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-01(E), Section: B.
500 $a Advisers: Myron I. Cybulsky; Jenny Jongstra-Bilen.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2016.
520 $a Dendritic cells are antigen presenting cells that play a key role in the initiation of the adaptive immune response and in chronic inflammatory diseases such as atherosclerosis. Resident intimal CD11c + cells are abundant in the normal arterial intima of mice, in regions predisposed to atherosclerosis. Upon induction of hypercholesterolemia, these cells engulf lipids and become the first foam cells in nascent lesions. However, their function in the normal aorta remains poorly understood. The purpose of this study is to show that their function is to protect the arterial intima against Chlamydia (C.) muridarum infection, and potentially against other intracellular and extracellular bacteria. This protection is achieved when intimal CD11c+ cells undergo reverse transendothelial migration (RTM) through the endothelium into the arterial circulation to remove the pathogen from the vessel wall.
520 $a Systemic pathogens and stimulation of pattern recognition receptors trigger two waves of RTM of intimal CD11c+ cells, each was followed by recovery through proliferation of the remaining cells. Both waves of RTM were dependent on up-regulated expression of CCR7 and its ligand CCL19 by intimal CD11c+ cells.
520 $a C. muridarum enters the arterial intima when infected circulating monocytes are recruited. The second wave of RTM removes the pathogen from the vessel wall. Inhibition of RTM (e.g. in Ccr7-/- mice) results in accumulation of C. muridarum in the vessel wall, which induces a local inflammatory response, that could be harmful to the arteria intima.
520 $a Hypercholesterolemia and lipid loading of intimal CD11c+ cells by feeding Ldlr--/- mice high fat diet for one week results in inhibition of RTM of CD11c+ foam cells. Lipid loading did not affect CCR7 or CCL19 induction in intimal cells and incubation with CCL19 did not rescue RTM in atherosclerotic lesions.
520 $a Studies in Asc-/- and Casp1 -/- mice that are deficient in the production of cleaved IL-1beta, as well as antibody blockade and rescue experiments revealed that RTM is dependent on IL-1beta production from the arterial endothelial cells. In addition, experiments with Il-1r1-/- mice suggest that RTM is dependent on receptor expression by the endothelial cells.
520 $a Future studies will continue to investigate other factors and mechanisms that might play a role in RTM of intimal CD11c+ cells, and explore how they can be used to induce RTM in atherosclerotic lesions as a potential preventative therapy to reduce atherosclerotic plaque burden.
590 $a School code: 0779.
650 4 $a Immunology. $3 611031
650 4 $a Cellular biology. $3 3172791
650 4 $a Microbiology. $3 536250
690 $a 0982
690 $a 0379
690 $a 0410
710 2 $a University of Toronto (Canada). $b Laboratory Medicine and Pathobiology. $3 3193014
773 0 $t Dissertation Abstracts International $g 78-01B(E).
790 $a 0779
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10140572