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Assembly of Slx4 Checkpoint Signalin...

Balint, Attila.

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Assembly of Slx4 Checkpoint Signaling Complexes Behind Stressed DNA Replication Forks.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Assembly of Slx4 Checkpoint Signaling Complexes Behind Stressed DNA Replication Forks./
作者:	Balint, Attila.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
面頁冊數:	141 p.
附註:	Source: Dissertation Abstracts International, Volume: 78-01(E), Section: B.
Contained By:	Dissertation Abstracts International78-01B(E).
標題:	Biochemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10137828
ISBN:	9781339934396

Assembly of Slx4 Checkpoint Signaling Complexes Behind Stressed DNA Replication Forks.
Balint, Attila.

Assembly of Slx4 Checkpoint Signaling Complexes Behind Stressed DNA Replication Forks. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 141 p.

Source: Dissertation Abstracts International, Volume: 78-01(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2016.

Obstructions to replication fork progression, referred to collectively as DNA replication stress, challenge genome stability. In S. cerevisiae, cells lacking RTT107 or SLX4 show genome instability, sensitivity to DNA replication stress, and are defective in the completion of DNA replication during recovery from replication stress. I demonstrate that Slx4 is recruited to chromatin behind stressed replication forks, in a region that is spatially distinct from that occupied by the replication machinery. Slx4 complex formation is nucleated by Mec1 phosphorylation of histone H2A, which is recognized by the constitutive Slx4 binding partner Rtt107. Slx4 is essential for recruiting the Mec1 activator Dpb11 behind stressed replication forks, and Slx4 complexes are important for full activity of Mec1. I propose that Slx4 complexes promote robust checkpoint signaling by Mec1 by stably recruiting Dpb11 within a discrete domain behind the replication fork, during DNA replication stress.

ISBN: 9781339934396Subjects--Topical Terms:

518028
Biochemistry.

Assembly of Slx4 Checkpoint Signaling Complexes Behind Stressed DNA Replication Forks.
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