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Diet, bacteria and inflammation: The...

Mohammed, Nadeem K.

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Diet, bacteria and inflammation: The intestinal mucosa and metabolic syndrome.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Diet, bacteria and inflammation: The intestinal mucosa and metabolic syndrome./
Author:	Mohammed, Nadeem K.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2012,
Description:	213 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.
Contained By:	Dissertation Abstracts International75-09B(E).
Subject:	Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3584166
ISBN:	9781321043174

Diet, bacteria and inflammation: The intestinal mucosa and metabolic syndrome.
Mohammed, Nadeem K.

Diet, bacteria and inflammation: The intestinal mucosa and metabolic syndrome. - Ann Arbor : ProQuest Dissertations & Theses, 2012 - 213 p.

Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.

Thesis (Ph.D.)--University of Kentucky, 2012.

Long term consumption of a high fat diet (HFD) increases the risk of developing Metabolic Syndrome and type 2 diabetes. This led us to hypothesize that long term HFD consumption impairs immune tolerance to the intestinal bacteria. Our studies had two goals. First, we characterized the effect of long term HFD consumption on the systemic immune response by comparing C57BL6 mice fed a HFD and low fat diet (LFD). Plasma immunoglobulin G (IgG) against Escherichia coli (LF-82), E. coli (Nissle 1917), Bacteroides thetaiotaomicron and Lactobacillus acidophilus were measured by a lab-developed ELISA. Fasting blood glucose and inflammation were measured in LFD mice and HFD mice. To test whether our findings were clinically relevant, anti-bacterial IgG and TNF-alpha were measured in plasma samples from lean healthy individuals, obese non-diabetics and obese diabetics. Our second aim was to investigate the relationship between HFD consumption and intestinal immunity. The effect of HFD consumption on immune responses in the GI tract was assessed by measuring fecal IgA levels in HFD mice and LFD mice. HFD mice had higher plasma IgG against the LF82 strain of Escherichia coli as well as higher plasma TNF-alpha, neutrophil percentage and fasting blood glucose levels. Obese diabetics had higher plasma IgG against the LF82 strain of E. coli than lean healthy controls. Studies on the effect of HFD on intestinal immunity revealed that HFD mice had lower fecal IgA than LFD mice. Our findings are novel in that they show an association between long term HFD consumption, systemic inflammatory immune responses to pathogenic intestinal bacteria and insulin resistance. These studies also showed that HFD consumption may impair intestinal immunity.

ISBN: 9781321043174Subjects--Topical Terms:

517777
Nutrition.

Diet, bacteria and inflammation: The intestinal mucosa and metabolic syndrome.
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100 1 $a Mohammed, Nadeem K. $3 3283795
245 1 0 $a Diet, bacteria and inflammation: The intestinal mucosa and metabolic syndrome.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2012
300 $a 213 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.
500 $a Advisers: Erik Eckhardt; Deneys van der Westhuyzen.
502 $a Thesis (Ph.D.)--University of Kentucky, 2012.
520 $a Long term consumption of a high fat diet (HFD) increases the risk of developing Metabolic Syndrome and type 2 diabetes. This led us to hypothesize that long term HFD consumption impairs immune tolerance to the intestinal bacteria. Our studies had two goals. First, we characterized the effect of long term HFD consumption on the systemic immune response by comparing C57BL6 mice fed a HFD and low fat diet (LFD). Plasma immunoglobulin G (IgG) against Escherichia coli (LF-82), E. coli (Nissle 1917), Bacteroides thetaiotaomicron and Lactobacillus acidophilus were measured by a lab-developed ELISA. Fasting blood glucose and inflammation were measured in LFD mice and HFD mice. To test whether our findings were clinically relevant, anti-bacterial IgG and TNF-alpha were measured in plasma samples from lean healthy individuals, obese non-diabetics and obese diabetics. Our second aim was to investigate the relationship between HFD consumption and intestinal immunity. The effect of HFD consumption on immune responses in the GI tract was assessed by measuring fecal IgA levels in HFD mice and LFD mice. HFD mice had higher plasma IgG against the LF82 strain of Escherichia coli as well as higher plasma TNF-alpha, neutrophil percentage and fasting blood glucose levels. Obese diabetics had higher plasma IgG against the LF82 strain of E. coli than lean healthy controls. Studies on the effect of HFD on intestinal immunity revealed that HFD mice had lower fecal IgA than LFD mice. Our findings are novel in that they show an association between long term HFD consumption, systemic inflammatory immune responses to pathogenic intestinal bacteria and insulin resistance. These studies also showed that HFD consumption may impair intestinal immunity.
520 $a KEYWORDS: Diabetes, Intestinal Bacteria, Inflammation, GI Tract, Diet.
590 $a School code: 0102.
650 4 $a Nutrition. $3 517777
650 4 $a Molecular chemistry. $3 1071612
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690 $a 0431
710 2 $a University of Kentucky. $b Nutritional Sciences. $3 3283796
773 0 $t Dissertation Abstracts International $g 75-09B(E).
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791 $a Ph.D.
792 $a 2012
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3584166