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Gene expression noise in stress resp...

Garcia-Bernardo, Javier.

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Gene expression noise in stress response as a survival strategy in fluctuating environments.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Gene expression noise in stress response as a survival strategy in fluctuating environments./
Author:	Garcia-Bernardo, Javier.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	93 p.
Notes:	Source: Masters Abstracts International, Volume: 54-04.
Contained By:	Masters Abstracts International54-04(E).
Subject:	Computer science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1586474
ISBN:	9781321681833

Gene expression noise in stress response as a survival strategy in fluctuating environments.
Garcia-Bernardo, Javier.

Gene expression noise in stress response as a survival strategy in fluctuating environments. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 93 p.

Source: Masters Abstracts International, Volume: 54-04.

Thesis (M.S.)--The University of Vermont and State Agricultural College, 2015.

This item is not available from ProQuest Dissertations & Theses.

Populations of cells live in uncertain environments, where they encounter large variations in nutrients, oxygen and toxic compounds. In the fluctuating environment, cells can sense their surroundings and express proteins to protect themselves against harmful substances. However, if the stressor appears infrequently or abruptly, sensing can be too costly or too slow, and cells cannot rely solely on it. To hedge against the sudden appearance of a stressor, cell populations can also rely on phenotypic diversification through bet-hedging. In bet-hedging, cells exploit noise in gene expression or use multistable genetic networks to produce an heterogeneous distribution of resistance-conferring protein levels. In this thesis, we analyze novel roles of noise in biological systems. Through a combination of modeling and stochastic simulations, we find that noise can coordinate multi-component stress response mechanisms in a subset of the population with no extra cost. In addition, we use evolutionary algorithms to analyze the conditions where the benefits provided by noise in gene expression are equivalent to those of a more complicated, bistable distribution of protein levels. Our results show that for cells living in noisy fluctuating environments, both noise in gene expression and bistability show similar growth rates, meaning that noise in gene expression can be an effective bet-hedging strategy.

ISBN: 9781321681833Subjects--Topical Terms:

523869
Computer science.

Gene expression noise in stress response as a survival strategy in fluctuating environments.
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500 $a Advisers: Mary J. Dunlop; Matthew J. Wargo.
502 $a Thesis (M.S.)--The University of Vermont and State Agricultural College, 2015.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Populations of cells live in uncertain environments, where they encounter large variations in nutrients, oxygen and toxic compounds. In the fluctuating environment, cells can sense their surroundings and express proteins to protect themselves against harmful substances. However, if the stressor appears infrequently or abruptly, sensing can be too costly or too slow, and cells cannot rely solely on it. To hedge against the sudden appearance of a stressor, cell populations can also rely on phenotypic diversification through bet-hedging. In bet-hedging, cells exploit noise in gene expression or use multistable genetic networks to produce an heterogeneous distribution of resistance-conferring protein levels. In this thesis, we analyze novel roles of noise in biological systems. Through a combination of modeling and stochastic simulations, we find that noise can coordinate multi-component stress response mechanisms in a subset of the population with no extra cost. In addition, we use evolutionary algorithms to analyze the conditions where the benefits provided by noise in gene expression are equivalent to those of a more complicated, bistable distribution of protein levels. Our results show that for cells living in noisy fluctuating environments, both noise in gene expression and bistability show similar growth rates, meaning that noise in gene expression can be an effective bet-hedging strategy.
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